KDRLKZ-2
KDRLKZ-2 is a small-molecule ligand of KLHDC2 E3 ligase (Kd = 95 nM), with an IC50 of 68 nM and 0.1 μM in alphaLISA and TR-FRET assays, respectively. KDRLKZ-2 binds to the substrate-binding pocket of the kelch domain of KLHDC2, mimics the interaction of natural substrates and displaces them. KDRLKZ-2 acts as an oligomer disruptor, regulates the oligomerization of the KLHDC2-EloB-EloC complex, and induces the dissociation of tetramers into smaller components. KDRLKZ-2 can be used in scaffold ligand studies of PROTAC degraders targeting KLHDC2.
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- Formel: C23H29N3O7
- Molecular Weight:459.49
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
KDRLKZ-2 competes with the native SelK peptide substrate for binding to purified KLHDC2 in alphaLISA displacement assays, with an IC50 of 0.068 μM[1].
KDRLKZ-2 competes with the native SelK peptide substrate for binding to purified KLHDC2 in TR-FRET displacement assays, with an IC50 of 0.1 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 459.49
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Formel C23H29N3O7
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SMILES
O=C(O)CN1C=C(N2C(C(C(C)CC)=CC3=C2CN(C(OCCOC)=O)CC3)=O)C=CC1=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
KDRLKZ-2 Related Classifications
HY-157559 Related Classifications
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