KRAS-IN-5
KRAS-IN-5 (Compound Ex 6) is an orally active and selective inhibitor targeting KRAS mutants (including KRASG12D, KRASG12V, KRASWT) with a GNE IC50 value of 1.3 nM against KRASG12D. KRAS-IN-5 blocks tumor cell proliferation by inhibiting KRAS-mediated signaling pathways (e.g., reducing ERK phosphorylation). KRAS-IN-5 is promising for research of KRAS mutation-related cancers, such as pancreatic cancer, colorectal cancer, lung cancer.
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- CAS. Nr.: 3082412-00-5
- Formel: C35H36F3N7O3
- Molecular Weight:659.70
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
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KRas G12D |
KRas G12V |
K-Ras WT |
Chemical Information
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CAS. Nr. 3082412-00-5
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Molecular Weight 659.70
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Formel C35H36F3N7O3
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SMILES
FC1=C(CC)C2=C(C=C(NN=C3C)C3=C2C4=C(F)C(N=C(OC[C@@]56CCCN5C[C@H](F)C6)N=C7N(CCCOC8)[C@@H]8CO9)=C7C9=N4)C=C1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
KRAS-IN-5 Related Classifications
HY-174261 Related Classifications
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