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Art. -Nr.: HY-188065

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LNP 509

LNP 509 is a selective I1 imidazoline receptor ligand with a bovine pK_i value of 6.27. LNP 509 exists mainly in the form of a more stable imine tautomer. Intracisternal administration of LNP 509 in anesthetized rabbits induces a dose-dependent decrease in mean arterial blood pressure. LNP 509 can be used in hypertension-related research.

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CAS. Nr.: 773839-36-4
Formel: C₁₃H₂₂N₂
Molecular Weight:206.33

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

LNP 509 Chemical Structure

CAS. Nr.: 773839-36-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

LNP 509 (compound 1e) (10^-9 to 10^-4 M; 40 min) binds to bovine chromaffin cell I1 imidazoline receptors with a pK_i of 6.27 and exhibits no detectable affinity for I2 imidazoline binding sites or α₂-adrenoceptors^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

LNP 509 (compound 1e) (10-1000 µg/kg; intracranial injection) causes a dose-dependent decrease in mean arterial pressure in anesthetized Zika strain rabbits; intravenous injection produces no effect^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 773839-36-4
Molecular Weight 206.33
Formel C₁₃H₂₂N₂
SMILES

CC1CC(NC(C2CC2)C3CC3)=NC1C
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Schann S, et al. Synthesis and biological evaluation of pyrrolinic isosteres of rilmenidine. Discovery of cis-/trans-dicyclopropylmethyl-(4,5-dimethyl-4,5-dihydro-3H-pyrrol-2-yl)-amine (LNP 509), an I1 imidazoline receptor selective ligand with hypotensive activity. Journal of medicinal chemistry. 2001 May 10;44(10):1588-93.

[2]. Remko M, et al. Theoretical study of structure, pKa, lipophilicity, solubility, absorption, and polar surface area of some centrally acting antihypertensives. Bioorganic & medicinal chemistry. 2006 Mar 15;14(6):1715-28. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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