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Art. -Nr.: HY-163724

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LW-216

LW-216 is a TrxR1 inhibitor that induces Apoptosis. LW-216 has anti-tumor activity.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 2146090-18-6
Formel: C₃₀H₃₁NO₅
Molecular Weight:485.57

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

LW-216 Chemical Structure

CAS. Nr.: 2146090-18-6

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Preis

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

LW-216 is a TrxR1 inhibitor that induces Apoptosis. LW-216 has anti-tumor activity^[1].

Alle TrxR Isoform-spezifische Produkte anzeigen :

TrxR1
TrxR2

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	1.1 μM Compound: 18l	Cytotoxicity in human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity in human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 28987604]
B16	IC₅₀	3.21 μM Compound: 18l	Cytotoxicity in mouse B16 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity in mouse B16 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 28987604]
HepG2	IC₅₀	4.66 μM Compound: 18l	Cytotoxicity in human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity in human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 28987604]
MCF7	IC₅₀	1.89 μM Compound: 18l	Cytotoxicity in human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity in human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 28987604]

In Vitro

LW-216 (5-25 μM, 24 h) selectively downregulates TrxR1 protein levels and induce apoptosis in NCI-H460 and A549 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

NCI-H460, A549
Concentration:

5, 15, 25 μM
Incubation Time:

24 h
Result:

Reduced TrxR1 expression in both cell lines.
Decreased the protein level of Bcl-2, PARP1 and Caspase-9, while increased Bax.

In Vivo

LW-216 (8 mg/kg, intravenously, once every two days for 18 days) inhibits tumor growth of NCI-H460 cells in a xenograft mouse model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

NCI-H460 cells in a xenograft mice model^[1]
Dosage:

8 mg/kg, once every two days for 18 days
Administration:

i.v.
Result:

Reduced bioluminescence intensity.
Increased the expression of apoptosis-related proteins Bax and Cleaved Caspase-3, while decreasing the expression of the proliferation-related protein Ki67.

Related Protocols :

Chemical Information

CAS. Nr. 2146090-18-6
Molecular Weight 485.57
Formel C₃₀H₃₁NO₅
SMILES

O=C1C=C(C2=CC=CC=C2)OC3=C(C(OCC4=CC=CC=C4)=CC(O)=C13)OCCCCN5CCCC5
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Wang R, et al. Inducing ubiquitination and degradation of TrxR1 protein by LW-216 promotes apoptosis in non-small cell lung cancer via triggering ROS production. Neoplasia. 2024 Jul;53:101004 [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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