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ML-792

39 Cited Publications
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Based on 39 publication(s) in Google Scholar

ML-792 is a potent and selective inhibitor of SAE/SUMO1 and SAE/SUMO2 in enzymatic assays (IC50 values of 3 and 11 nM, respectively) compared with NAE/NEDD8 and UAE/ubiquitin (IC50> values of 32 μM and >100 μM, respectively).

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  • Reinheit: 99.76%
  • CAS. Nr.: 1644342-14-2
  • Formel: C21H23BrN6O5S
  • Molecular Weight:551.41
  • Speicherung:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • ML-792 Chemical Structure
    ML-792 Chemical Structure
  • Experimental Validation Results for ML-792
  • Experimental Validation Results for ML-792
  • Experimental Validation Results for ML-792
  • Experimental Validation Results for ML-792
  • Experimental Validation Results for ML-792
  • Experimental Validation Results for ML-792
CAS. Nr.: 1644342-14-2
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  • ML-792 Chemical Structure
    ML-792 Chemical Structure
    1/16
  • 1/16

    ML-792 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Aug 6;16(1):7248. [Abstract]

    Customer Validation
     Cells were treated with ML-792 (0.5 µM) from days −2 to 9 of adipocyte differentiation, fluorescence and brightfield microscopy images of cells stained with Bodipy lipid dye on day 9.

  • 1/16

    ML-792 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Aug 6;16(1):7248. [Abstract]

    Customer Validation
     Cells treated with either vehicle or 0.5 µM ML-792 throughout the differentiation with alkaline phosphatase staining.

  • 1/16

    ML-792 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Aug 29;16(1):8074. [Abstract]

    Customer Validation
     Western blot of the protein expression of SERCA2 SUMOylation in human VSMCs infected with Ad-NEXN, treated with ML792 (10 μM), and then cultured for 7 days in GM.

  • 1/16

    ML-792 purchased from MedChemExpress. Usage Cited in: Mol Cell. 2024 Sep 5;84(17):3271-3287.e8. [Abstract]

    Customer Validation
     Real-time qPCR analysis of SASP genes in the presence of ML-792 (0,1,10 nM).

  • 1/16

    ML-792 purchased from MedChemExpress. Usage Cited in: Mol Cell. 2023 Feb 16;83(4):539-555.e7. [Abstract]

    Customer Validation
     HEK293T cells transfected with FLAG-HNRNPA2 were treated with various concentrations of ML-792 (0, 2, 5 μM) for 16 h. HNRNPA2SUMO and SUMO1 conjugates were detected using anti-FLAG and anti-SUMO1 antibodies, respectively.

  • 1/16

    ML-792 purchased from MedChemExpress. Usage Cited in: Mol Cell. 2020 Jul 2;79(1):54-67.e7. [Abstract]

    Customer Validation
     Treatment of cells with the SUMO inhibitor ML-792 for 4 or 24 h causes a dramatic recruitment of FUSP525L in G3BP1-positive SGs. By contrast, wild-type FUS does not accumulate in these structures upon inhibition of SUMOylation.

  • ML-792