ML404
ML404 (Compound 38) is an inhibitor of the mitochondrial permeability transition pore (mtPTP), which can suppress mitochondrial swelling (EC50=4.9 nM) and only disrupts mitochondrial coupling (an adverse effect) at concentrations > 100 μM. ML404 can be utilized in research related to multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), muscular dystrophies (MD), myocardial infarction, and stroke.
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- CAS. Nr.: 1826026-00-9
- Formel: C17H13ClN2O3
- Molecular Weight:328.75
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
Chemical Information
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CAS. Nr. 1826026-00-9
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Molecular Weight 328.75
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Formel C17H13ClN2O3
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SMILES
O=C(NC1=CC(Cl)=CC=C1C)C2=NOC(C3=CC=CC(O)=C3)=C2
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Sileikyte J, et al. Small molecules targeting the mitochondrial permeability transition[J]. Probe Reports from the NIH Molecular Libraries Program [Internet], 2015. [Content Brief]
[2]. Roy S, et al. Discovery, synthesis, and optimization of diarylisoxazole‐3‐carboxamides as potent inhibitors of the mitochondrial permeability transition pore[J]. ChemMedChem, 2015, 10(10): 1655-1671. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
ML404 Related Classifications
HY-114898 Related Classifications
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