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Art. -Nr.: HY-142648

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MLT-985

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

MLT-985 is a selective allosteric and orally active MALT1 inhibitor with an IC₅₀ value of 3 nM. MLT-985 can suppress cell growth and aberrant CARD11/BCL10/MALT1 complex signaling. MLT-985 can be used for the research of cancer, such as B cell malignancies.

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Reinheit: 99.49%
CAS. Nr.: 1832576-25-6
Formel: C₁₇H₁₅Cl₂N₉O₂
Molecular Weight:448.27

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

MLT-985 Chemical Structure

CAS. Nr.: 1832576-25-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
Publications (1)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
BJAB	IC₅₀	>10 μM Compound: 11; MLT-985	Growth inhibition of human BJAB cells grown in soft agar Growth inhibition of human BJAB cells grown in soft agar	[PMID: 33216547]
OCI-Ly3	EC₅₀	0.12 μM Compound: 9	Antiproliferative activity against human OCILY3 cells by cell proliferation assay Antiproliferative activity against human OCILY3 cells by cell proliferation assay	[PMID: 31129051]
OCI-Ly3	IC₅₀	0.03 μM Compound: 11; MLT-985	Inhibition of ROS production in human OCILY3 cells Inhibition of ROS production in human OCILY3 cells	[PMID: 33216547]
OCI-Ly3	IC₅₀	0.24 μM Compound: 11; MLT-985	Growth inhibition of human OCILY3 cells grown in soft agar Growth inhibition of human OCILY3 cells grown in soft agar	[PMID: 33216547]

In Vitro

MLT-985 (19.5-10000 nM, 24 h) inhibits the growth of CARD11 mutant OCI-Ly3 cells growth^[1].
MLT-985 (10-1000 nM, 24 h) inhibits MALT1 protease activity in ABC-DLBCL cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

ABC-DLBCL cells
Concentration:

10, 50, 100, 500 and 1000 nM
Incubation Time:

24 h
Result:

Blocked cleavage of MALT1 substrates BCL10, CYLD and RELB.

Parmacokinetics

Species	Dose	Route	CL	T_1/2	V_ss	C_max	F
Mice^[1]	1 mg/kg	i.v.	5 mL/min/kg	3.7 h	1.4 L/kg	/	/
Mice^[1]	3 mg/kg	p.o.	/	/	/	0.0017 μM	83 %
Rat^[1]	1 mg/kg	i.v.	7 mL/min/kg	8.5 h	4.2 L/kg	/	/
Rat^[1]	3 mg/kg	p.o.	/	/	/	0.0007 μM	79 %

In Vivo

MLT-985 (30 mg/kg, p.o., twice daily) inhibits tumor growth in CARD11-mutant ABC-DLBCL xenograft model OCI Ly3.^[1].
MLT-985 (30 mg/kg, i.g., starting day 13 post-engraftment) prolongs survival in OCI-Ly3 tumor xenograft mice models^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

OCI-Ly3 tumor xenograft mice models^[2]
Dosage:

30 mg/kg
Administration:

Orally gavage, starting day 13 post-engraftment
Result:

Showed median survival of 41 days.

Chemical Information

CAS. Nr. 1832576-25-6
Appearance Solid
Molecular Weight 448.27
Formel C₁₇H₁₅Cl₂N₉O₂
Color White to off-white
SMILES

CO[C@H](C1=C(NC(NC2=CN=C(N3N=CC=N3)C(Cl)=C2)=O)C=NC4=CC(Cl)=NN14)C
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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Journal Impact Factor

Nat Cancer

Targeting both death and paracaspase domains of MALT1 with antisense oligonucleotides overcomes resistance to immune-checkpoint inhibitors. [Abstract]

2025 Apr;6(4):702-717. PMID: 40075237

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (223.08 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.2308 mL

11.1540 mL

22.3080 mL

5 mM

0.4462 mL

2.2308 mL

4.4616 mL

10 mM

0.2231 mL

1.1154 mL

2.2308 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Quancard J, et al. Optimization of the In Vivo Potency of Pyrazolopyrimidine MALT1 Protease Inhibitors by Reducing Metabolism and Increasing Potency in Whole Blood. J Med Chem. 2020 Dec 10;63(23):14594-14608. [Content Brief]

[2]. Sara Elgamal, et al. Development of ZE66-0205, a Novel MALT1 Degrader for Treatment of B-Cell Malignancies, Blood, Volume 144, Supplement 1, 2024, Page 2783, ISSN 0006-4971.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.2308 mL	11.1540 mL	22.3080 mL	55.7700 mL
	5 mM	0.4462 mL	2.2308 mL	4.4616 mL	11.1540 mL
	10 mM	0.2231 mL	1.1154 mL	2.2308 mL	5.5770 mL
	15 mM	0.1487 mL	0.7436 mL	1.4872 mL	3.7180 mL
	20 mM	0.1115 mL	0.5577 mL	1.1154 mL	2.7885 mL
	25 mM	0.0892 mL	0.4462 mL	0.8923 mL	2.2308 mL
	30 mM	0.0744 mL	0.3718 mL	0.7436 mL	1.8590 mL
	40 mM	0.0558 mL	0.2788 mL	0.5577 mL	1.3942 mL
	50 mM	0.0446 mL	0.2231 mL	0.4462 mL	1.1154 mL
	60 mM	0.0372 mL	0.1859 mL	0.3718 mL	0.9295 mL
	80 mM	0.0279 mL	0.1394 mL	0.2788 mL	0.6971 mL
	100 mM	0.0223 mL	0.1115 mL	0.2231 mL	0.5577 mL

Keywords

MLT-985

1 Cited Publications

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise

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MLT-985

Immunology/Inflammation Compound Library

Metabolism/Protease Compound Library

NF-κB Signaling Compound Library

Anti-Cancer Compound Library

Anti-Aging Compound Library

Orally Active Compound Library

Heterocyclic Compound Library

Protease Inhibitor Library

Highly Selective Inhibitors Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Lactylation Compound Library

Publications Citing Use of MedChemExpress (MCE) MLT-985

Biologische Aktivität

Chemical Information

Publications (1)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

MLT-985

Immunology/Inflammation Compound Library

Metabolism/Protease Compound Library

NF-κB Signaling Compound Library

Anti-Cancer Compound Library

Anti-Aging Compound Library

Orally Active Compound Library

Heterocyclic Compound Library

Protease Inhibitor Library

Highly Selective Inhibitors Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Lactylation Compound Library

Publications Citing Use of MedChemExpress (MCE) MLT-985

Biologische Aktivität

Chemical Information

Publications (1)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

MLT-985 Related Classifications

HY-142648 Related Classifications