Art. -Nr.: HY-172550

MS7710

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MS7710 is a hyperpolarization-activated cyclic nucleotide-gated (HCN) channel inhibitor with blood-brain barrier permeability and an excellent brain/plasma concentration ratio. MS7710 inhibits HCN channel-mediated I_h current, and reduces the firing frequency and burst activity of dopaminergic neurons in the ventral tegmental area. MS7710 ameliorates chronic social defeat stress-induced deficits in social interaction and impairments in reward-related cognitive flexibility in mice. MS7710 exerts only limited effects on ventral tegmental area dopaminergic neuron activity, social interaction, exploratory behavior, locomotor activity or sucrose preference in control mice. MS7710 is applicable to the research of major depressive disorder.

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Reinheit: 98.86%
CAS. Nr.: 3095336-10-7
Formel: C₂₇H₃₆N₂O₅
Molecular Weight:468.59

Speicherung:

Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

MS7710 Chemical Structure

CAS. Nr.: 3095336-10-7

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Biologische Aktivität
- Beschreibung
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

MS7710 inhibits the firing frequency and burst activity of dopamine neurons in the ventral tegmental area (VTA) in brain slice electrophysiological experiments^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	T_1/2	Plasma Concentration
Mice^[2]	20 mg/kg	i.p.	0.82	0.79
Mice^[2]	20 mg/kg	i.p.	0.65	0.58

In Vivo

MS7710 (1-10 mg/kg; i.p.; single dose) significantly reduces hyperactive firing rate and bursting activity of ventral tegmental area dopamine neurons in male chronic social defeat stress-susceptible mice^[2].
MS7710 (1 mg/kg; i.p.; single dose) significantly reduces hyperactive firing rate and bursting activity of ventral tegmental area dopamine neurons in female chronic social defeat stress-susceptible mice^[2].
MS7710 (5 mg/kg; i.p.; single dose) produces long-lasting (14-day) amelioration of social interaction deficits and reward-related cognitive inflexibility in male and female chronic social defeat stress-susceptible mice^[2].
MS7710 (20 mg/kg; i.p.; single dose) achieves a brain/plasma partition coefficient of 0.42 in male stress-naive mice and 0.21 in female stress-naive mice, demonstrating superior blood-brain barrier permeability relative to Cilobradine (HY-18940)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6J (male, 8 weeks old, chronic social defeat stress-induced susceptible)^[2]
Dosage:

1 mg/kg; 10 mg/kg
Administration:

i.p.; single dose
Result:

Significantly reduced ventral tegmental area dopamine neuron firing rate and bursting activity at 1 mg/kg compared to baseline.
Significantly reduced ventral tegmental area dopamine neuron firing rate and bursting activity at 10 mg/kg compared to baseline.

Animal Model:

C57BL/6J (female, 8 weeks old, chronic social defeat stress-induced susceptible)^[2]
Dosage:

1 mg/kg
Administration:

i.p.; single dose
Result:

Significantly reduced ventral tegmental area dopamine neuron firing rate and bursting activity compared to baseline.

Animal Model:

C57BL/6J (male and female, 8 weeks old, chronic social defeat stress-induced susceptible)^[2]
Dosage:

5 mg/kg
Administration:

i.p.; single dose
Result:

Significantly increased social interaction ratios 14 days post-injection and improved probabilistic reversal reward learning task performance in male susceptible mice: required fewer sessions to re-establish preference for the new 80% reward lever and showed higher correct choice percentages during the reversal phase compared to saline controls.
Significantly increased social interaction ratios 14 days post-injection and improved probabilistic reversal reward learning task performance in female susceptible mice: required fewer sessions to re-establish preference for the new 80% reward lever and showed higher correct choice percentages during the reversal phase compared to saline controls.

Animal Model:

C57BL/6J (male and female, 8 weeks old, stress-naive)^[2]
Dosage:

20 mg/kg
Administration:

i.p.; single dose
Result:

Achieved a brain/plasma partition coefficient (K_p) of 0.42 in male mice and 0.21 in female mice, indicating significantly improved blood-brain barrier permeability compared to the parent compound Cilobradine.

Chemical Information

CAS. Nr. 3095336-10-7
Appearance Oil
Molecular Weight 468.59
Formel C₂₇H₃₆N₂O₅
Color Off-white to light yellow
SMILES

COC1=CC=CC(OCCN2CCC[C@H](CN3C(CC(C=C(OC)C(OC)=C4)=C4CC3)=O)C2)=C1
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (213.41 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.1341 mL

10.6703 mL

21.3406 mL

5 mM

0.4268 mL

2.1341 mL

4.2681 mL

10 mM

0.2134 mL

1.0670 mL

2.1341 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 5 mg/mL (10.67 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 5 mg/mL (10.67 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Teichman E M. Multimodal Targeting of Neuronal HCN Channels for Antidepressant Drug Discovery[D]. Icahn School of Medicine at Mount Sinai, 2024.

[2]. Teichman EM, et al. Design and validation of novel brain-penetrant HCN channel inhibitors to ameliorate social stress-induced susceptible phenotype. Mol Psychiatry. 2025;30(9):3937-3950. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.1341 mL	10.6703 mL	21.3406 mL	53.3515 mL
	5 mM	0.4268 mL	2.1341 mL	4.2681 mL	10.6703 mL
	10 mM	0.2134 mL	1.0670 mL	2.1341 mL	5.3352 mL
	15 mM	0.1423 mL	0.7114 mL	1.4227 mL	3.5568 mL
	20 mM	0.1067 mL	0.5335 mL	1.0670 mL	2.6676 mL
	25 mM	0.0854 mL	0.4268 mL	0.8536 mL	2.1341 mL
	30 mM	0.0711 mL	0.3557 mL	0.7114 mL	1.7784 mL
	40 mM	0.0534 mL	0.2668 mL	0.5335 mL	1.3338 mL
	50 mM	0.0427 mL	0.2134 mL	0.4268 mL	1.0670 mL
	60 mM	0.0356 mL	0.1778 mL	0.3557 mL	0.8892 mL
	80 mM	0.0267 mL	0.1334 mL	0.2668 mL	0.6669 mL
	100 mM	0.0213 mL	0.1067 mL	0.2134 mL	0.5335 mL

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MS7710

Membrane Transporter/Ion Channel Compound Library

CNS-Penetrant Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Ion Channel Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

MS7710

Membrane Transporter/Ion Channel Compound Library

CNS-Penetrant Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Ion Channel Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

MS7710 Related Classifications

HY-172550 Related Classifications