Namoline
Namoline, a γ-pyrone, is a selective and reversible Lysine-specific demethylase 1 (LSD1) inhibitor with an IC50 of 51 μM in a HRP-coupled enzymatic assay. Namoline impairs LSD1 demethylase activity and blocks cell proliferation. Namoline has the potential for androgen-dependent prostate cancer research.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 342795-11-3
- Formel: C10H3ClF3NO4
- Molecular Weight:293.58
-
Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
- Protokoll
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
-
HY-103713
SeclidemstatLSD1 Inhibitor -
HY-129388B
Pulrodemstat benzenesulfonateLSD1 Inhititor -
HY-12782T
Iadademstat dihydrochlorideKDM1A Inhibitor -
HY-18632A
GSK2879552 dihydrochlorideLSD1/KDM1A Inhibitor -
HY-110277
S2101LSD1 Inhibitor -
HY-110130
RN-1 dihydrochlorideLSD1 Inhibitor -
HY-103085
T-3775440 hydrochlorideLSD1 Inhibitor -
HY-103713A
Seclidemstat mesylateLSD1 Inhibitor -
HY-103713R
Seclidemstat (Standard)Reference Standard -
HY-103085R
T-3775440 hydrochloride (Standard)Reference Standard -
HY-103713AR
Seclidemstat mesylate (Standard)Reference Standard
Biologische Aktivität
Beschreibung
In Vitro
Namoline (50 μM; 24, 48, 72 hours) reduces androgen-induced proliferation of LNCaP cells[1].
Namoline (50 μM) specifically impairs AR agonist R1881-induced (1 nM) demethylation of H3K9me1 and H3K9me2 in LNCaP cells[1].
Namoline (50 μM) does not affect the enzymatic activities of MAOs under these conditions[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
- BrdU Incorporation Assay
- Somatic Cell Culture
- CFSE Dye Dilution Proliferation Assay
- Dye-dilution cell tracking and proliferation staining
- CCK-8/WST-8 Cell Proliferation Assay
- Protocol for Cell Cycle
- Cell Counting-Based Growth Curve Assay
- Colony Formation (Clonogenic) Assay
- Cell Viability Determination by MTT Colorimetric Assay
- EdU Incorporation Assay (Click Chemistry-Based DNA Synthesis Measurement)
- Ki-67 Immunostaining Proliferation Assay
- PCNA Immunodetection Proliferation Assay
- Protocol for Cell Counting and Cell Density Analysis
- Research Protocol for Endocrine Diseases
- MTT Cell Proliferation Assay
Chemical Information
-
CAS. Nr. 342795-11-3
-
Molecular Weight 293.58
-
Formel C10H3ClF3NO4
-
SMILES
O=C1C(Cl)=C(C(F)(F)F)OC2=CC=C([N+]([O-])=O)C=C12
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Namoline Related Classifications
HY-115747 Related Classifications
Powered by Bioz