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Art. -Nr.: HY-184558

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NP7r

NP7r is an antioxidant and neuroprotective agent. NP7r regulates oxidative stress, upregulates downstream antioxidant genes, reduces mitochondrial ROS, initiates Autophagy and clears α-synuclein aggregates. NP7r alleviates dopaminergic neuron degeneration, restores fat content, reduces lipid peroxidation, and improves motor impairment and abnormal food perception. NP7r is applicable to the research of Parkinson's disease.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 2641092-28-4
Formel: C₂₆H₂₀O₃
Molecular Weight:380.44

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

NP7r Chemical Structure

CAS. Nr.: 2641092-28-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
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Biologische Aktivität

Beschreibung

Alle α-synuclein Isoform-spezifische Produkte anzeigen :

In Vivo

NP7r (10-80 μM; 48 h) exerts neuroprotective effects in an α-synuclein-expressing C. elegans Parkinson's disease model, with mechanisms involving a statistically significant reduction in mitochondrial ROS levels, approximately 30% decrease in α-synuclein aggregation, and upregulation of antioxidant and autophagy-related pathways^[1].
NP7r (10 μM) protects *Caenorhabditis elegans* against 6-OHDA (HY-B1081)-induced dopaminergic neuron degeneration, restoring the total fluorescence intensity of dopaminergic neurons to 96.28% of that in the control group^[1].
NP7r (10 μM) alleviates 6-OHDA-induced growth and behavioral defects in wild-type *Caenorhabditis elegans*, restoring its movement and feeding-related behaviors to levels close to those of the control group^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

NL5901 pkIs2386 [unc-54p::alpha-synuclein:YFP + unc-119(+)]^[1]
Dosage:

10 μM; 20 μM; 40 μM; 80 μM
Administration:

nematode growth medium; 48 hours
Result:

Significantly reduced mitochondrial ROS levels in NL5901 worms (effect dependent on skn-1 gene).
Decreased α-synuclein-YFP fluorescence intensity by ~30% relative to untreated controls.
Reduced MDA levels and partially restored lipid droplet area in NL5901 worms.
Upregulated mRNA levels of skn-1, gst-4, gcs-1, cct-2, cct-3, cct-4, cct-6, cct-7, cct-8, lgg-1, unc-51, epg-5, epg-8, vps-35, and atg-7.
Downregulated daf-16 and sod-3 mRNA levels.
Increased GSH levels and restored GST-4::GFP fluorescence intensity in 6-OHDA-treated CL2166 worms.
Confirmed α-synuclein clearance effect dependent on cct-6, lgg-1, and unc-51 genes.

Animal Model:

BZ555 egls1[Pdat-1::gfp]^[1]
Dosage:

10 μM
Administration:

nematode growth medium; post-6-OHDA exposure
Result:

Restored total dopaminergic neuron fluorescence intensity to 96.28% of untreated BZ555 levels, representing a 36.23% increase relative to 6-OHDA-only treated worms.
Restored fluorescence intensity of cephalic (CEP), anterior deirid (ADE), and posterior deirid (PDE) dopaminergic neurons.

Animal Model:

N2^[1]
Dosage:

10 μM
Administration:

nematode growth medium; post-6-OHDA exposure
Result:

Restored 6-OHDA-reduced body length, tail thrashing frequency, slowing rate, travel distance, velocity, and body bend frequency in N2 worms to levels statistically comparable to untreated controls.

Chemical Information

CAS. Nr. 2641092-28-4
Molecular Weight 380.44
Formel C₂₆H₂₀O₃
SMILES

O=C1CCC2=C1C(C3=CC=CC=C3)=CC(C4=CC=C(C=C4)O)(O2)C5=CC=CC=C5
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Han RT, et al. Pyran compound 7r exerts neuroprotective effects against Parkinson's disease via modulating oxidative stress and autophagy. iScience. 2026 Jun 8;29(6):116233. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Chemical Information
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NP7r

Alle α-synuclein Isoform-spezifische Produkte anzeigen