PG-931
Based on 1 Customer Validation
PG-931, an analog of SHU 9119 (HY-P0227), is a potent melanocortin 4 (MC4) receptor (IC50=0.58 nM) agonist and is more selective than for the hMC3R (IC50=55 nM) or the hMC5R (IC50=2.4 nM). PG-931 can reverse haemorrhagic shock and prevent multiple organ damage in vivo.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.60%
- CAS. Nr.: 667430-81-1
- Formel: C59H85N15O11
- Molecular Weight:1180.40
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
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MC4R |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wistar rats[2]
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Dosage:13-108 nmol/kg
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Administration:Intravenous injection; single dose
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Result:Exhibitd an anti-shock effect occurred at nanomolar doses.
Chemical Information
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CAS. Nr. 667430-81-1
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Appearance Solid
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Molecular Weight 1180.40
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Formel C59H85N15O11
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Color White to off-white
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Sequence
Ac-{Nle}-Asp-Pro-{d-Phe}-Arg-Trp-Lys-Pro-Val-NH2 (Lactam bridge: Asp2-Lys7)
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Sequence Shortening
Ac-{Nle}-DP-{d-Phe}-RWKPV-NH2 (Lactam bridge: Asp2-Lys7)
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Lösungsmittel & Löslichkeit
H2O : 100 mg/mL (84.72 mM; Need ultrasonic)
DMSO : ≥ 100 mg/mL (84.72 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (283 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. D Giuliani, et al. Selective melanocortin MC4 receptor agonists reverse haemorrhagic shock and prevent multiple organ damage. Br J Pharmacol [Content Brief]
[2]. P Grieco, et al. Extensive structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5. J Pept Res [Content Brief]
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 0.8472 mL | 4.2359 mL | 8.4717 mL | 21.1793 mL |
| 5 mM | 0.1694 mL | 0.8472 mL | 1.6943 mL | 4.2359 mL | |
| 10 mM | 0.0847 mL | 0.4236 mL | 0.8472 mL | 2.1179 mL | |
| 15 mM | 0.0565 mL | 0.2824 mL | 0.5648 mL | 1.4120 mL | |
| 20 mM | 0.0424 mL | 0.2118 mL | 0.4236 mL | 1.0590 mL | |
| 25 mM | 0.0339 mL | 0.1694 mL | 0.3389 mL | 0.8472 mL | |
| 30 mM | 0.0282 mL | 0.1412 mL | 0.2824 mL | 0.7060 mL | |
| 40 mM | 0.0212 mL | 0.1059 mL | 0.2118 mL | 0.5295 mL | |
| 50 mM | 0.0169 mL | 0.0847 mL | 0.1694 mL | 0.4236 mL | |
| 60 mM | 0.0141 mL | 0.0706 mL | 0.1412 mL | 0.3530 mL | |
| 80 mM | 0.0106 mL | 0.0529 mL | 0.1059 mL | 0.2647 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
PG-931 Related Classifications
HY-P1208 Related Classifications
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