Pladienolide A
Based on 1 Customer Validation
Pladienolide A is a natural product derived from Streptomyces platensis. Pladienolide A inhibits hypoxia-induced VEGF promoter-driven PLAP reporter gene. Pladienolide A can be used for research on glioma.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit : 98.01%
- CAS. Nr.: 445493-22-1
- Formel: C28H46O7
- Molecular Weight:494.66
-
Speicherung:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
-
Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen
More
Biologische Aktivität
Beschreibung
In Vitro
Pladienolide A (967.5 nM; 72 h) inhibits U251 human glioma cell proliferation with an IC50 of 967.5 nM[2].
Pladienolide A (451.5 nM; 18 h) inhibits hypoxia-induced VEGF-PLAP secretion in U251 VEGF-PLAP reporter cells with an IC50 of 451.5 nM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS. Nr. 445493-22-1
-
Appearance Solid
-
Molecular Weight 494.66
-
Formel C28H46O7
-
Color Off-white to light yellow
-
SMILES
C/C([C@@H]1[C@H](/C=C/[C@@H]([C@](O)(CC[C@H](CC(O1)=O)O)C)O)C)=C\C=C\[C@@H](C)C[C@@H]2[C@@](O2)([H])[C@H](C)[C@@H](O)CC
-
Structure Classification
-
Initial Source
Streptomyces platensis
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 5 mg/mL (10.11 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
-
Data Sheet (271 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0216 mL | 10.1080 mL | 20.2159 mL | 50.5398 mL |
| 5 mM | 0.4043 mL | 2.0216 mL | 4.0432 mL | 10.1080 mL | |
| 10 mM | 0.2022 mL | 1.0108 mL | 2.0216 mL | 5.0540 mL |
Pladienolide A Related Classifications
HY-N12655 Related Classifications
Powered by Bioz