CD72
CD72 is a B-lineage-restricted type II transmembrane lectin of the C-type lectin family that acts as a counterweight to activating B-cell receptor signals. Its cytoplasmic tail carries two ITIM motifs that recruit SHP-1, raising the activation threshold of immature B cells and thereby contributing to central tolerance; CD72 is strongest on immature and marginal-zone B cells and wanes with differentiation. The binding of ligand CD100 (semaphorin 4D) neutralizes its inhibitory function, converting CD72 into a positive regulator during T-cell-dependent antibody responses. CD72 polymorphisms have been associated with systemic lupus erythematosus susceptibility.
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CD72 Recombinant Proteins (5)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
