Dectin-1
Dectin-1, encoded by CLEC7A, is the principal mammalian receptor for beta-glucans, the major cell-wall polysaccharides of fungi. Although grouped with C-type lectins, its lectin-like domain binds beta-1,3-glucan independently of a canonical carbohydrate-recognition fold. Dectin-1 signals through a hemITAM that recruits Syk and the CARD9-BCL10-MALT1 scaffold, triggering phagocytosis, respiratory burst, and production of IL-1β, IL-6, and TNF-α. It is expressed on macrophages, dendritic cells, and neutrophils and cooperates with TLRs to shape antifungal Th17 responses; human Dectin-1 deficiency causes chronic mucocutaneous candidiasis. Recombinant Dectin-1 protein underpins beta-glucan sensing assays, adjuvant development, and antifungal-immunity research.
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Dectin-1 Recombinant Proteins (6)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
