Art. -Nr.: HY-148255

QN523

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QN523 is a novel scaffold with agent-like properties, showing potent in vitro cytotoxicity in a panel of 12 cancer cell lines. QN523 induces apoptosis and autophagy. QN523 can be used in research of cancer.

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Reinheit: 99.19%
CAS. Nr.: 878581-60-3
Formel: C₁₄H₁₀N₄O
Molecular Weight:250.26

Speicherung:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

QN523 Chemical Structure

CAS. Nr.: 878581-60-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
BXPC-3	IC₅₀	1.8 μM Compound: QN523	Antiproliferative activity against human BXPC-3 cells measured after 72 hrs by MTT assay Antiproliferative activity against human BXPC-3 cells measured after 72 hrs by MTT assay	[PMID: 36692906]
BXPC-3	IC₅₀	3.3 μM Compound: QN523; 2	Cytotoxicity against human BXPC-3 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Cytotoxicity against human BXPC-3 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 35439009]
HCT-116	IC₅₀	0.1 μM Compound: QN523; 2	Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 35439009]
HEK293	IC₅₀	0.15 μM Compound: QN523; 2	Cytotoxicity against HEK293 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Cytotoxicity against HEK293 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 35439009]
HEK293	IC₅₀	0.2 μM Compound: QN523	Cytotoxicity against HEK293 cells measured after 72 hrs by MTT assay Cytotoxicity against HEK293 cells measured after 72 hrs by MTT assay	[PMID: 36692906]
Hep 3B2	IC₅₀	0.21 μM Compound: QN523; 2	Antiproliferative activity against human Hep3B cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human Hep3B cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 35439009]
HepG2	IC₅₀	0.5 μM Compound: QN523; 2	Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 35439009]
HFF-1	IC₅₀	>30 μM Compound: QN523; 2	Cytotoxicity against human HFF-1 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Cytotoxicity against human HFF-1 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 35439009]
HFF-1	IC₅₀	>30 μM Compound: QN523	Cytotoxicity against HFF-1 cells measured after 72 hrs by MTT assay Cytotoxicity against HFF-1 cells measured after 72 hrs by MTT assay	[PMID: 36692906]
Jurkat	IC₅₀	0.1 μM Compound: QN523; 2	Antiproliferative activity against human Jurkat cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human Jurkat cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 35439009]
MIA PaCa-2	IC₅₀	0.11 μM Compound: QN523; 2	Cytotoxicity against human MIA PaCa-2 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Cytotoxicity against human MIA PaCa-2 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 35439009]
MIA PaCa-2	IC₅₀	0.3 μM Compound: QN523	Antiproliferative activity against human MIA PaCa-2 cells measured after 72 hrs by MTT assay Antiproliferative activity against human MIA PaCa-2 cells measured after 72 hrs by MTT assay	[PMID: 36692906]
OVCAR-8	IC₅₀	0.3 μM Compound: QN523; 2	Antiproliferative activity against human OVCAR-8 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human OVCAR-8 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 35439009]
Panc02	IC₅₀	0.3 μM Compound: QN523	Antiproliferative activity against mouse Panc02 cells measured after 72 hrs by MTT assay Antiproliferative activity against mouse Panc02 cells measured after 72 hrs by MTT assay	[PMID: 36692906]
PANC-1	IC₅₀	0.5 μM Compound: QN523; 2	Cytotoxicity against human PANC-1 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Cytotoxicity against human PANC-1 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 35439009]
PANC-1	IC₅₀	1.7 μM Compound: QN523	Antiproliferative activity against human PANC-1 cells measured after 72 hrs by MTT assay Antiproliferative activity against human PANC-1 cells measured after 72 hrs by MTT assay	[PMID: 36692906]
SNU-387	IC₅₀	5.73 μM Compound: QN523; 2	Antiproliferative activity against human SNU-387 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human SNU-387 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 35439009]
SNU-398	IC₅₀	1.9 μM Compound: QN523; 2	Antiproliferative activity against human SNU-398 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human SNU-398 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 35439009]
SNU-449	IC₅₀	0.4 μM Compound: QN523; 2	Antiproliferative activity against human SNU-449 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human SNU-449 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 35439009]
SNU-475	IC₅₀	2.67 μM Compound: QN523; 2	Antiproliferative activity against human SNU-475 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human SNU-475 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 35439009]

In Vitro

QN523 (72 h) has cytotoxicity with IC₅₀ values ranging from 0.1 to 5.7 μM across 12 cell lines^[1].
QN523 (0.1 and 0.5 μM; 24 and 48 h; MIA PaCa-2 cells) arrests cell cycle at S phase and delays for pancreatic cancer cells to enter the G2-M phase. QN523 induces apoptosis and autophagy of MIA PaCa-2 Cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis^[1]

Cell Line:

MIA PaCa-2 cells
Concentration:

0.1 and 0.5 μM
Incubation Time:

24 and 48 hours
Result:

Delayed for pancreatic cancer cells to enter the G2-M phase because of accumulation of cells in the S phase.

Apoptosis Analysis^[1]

Cell Line:

MIA PaCa-2 cells
Concentration:

0.1 and 0.5 μM
Incubation Time:

24 and 48 hours
Result:

Increased the number of apoptotic cell in time- and dose-dependent manner.

In Vivo

QN523 (10 and 20 mg/kg; i.p.; daily, for 44 d) inhibits tumor growth in mice of pancreatic cancer xenografts^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

NOD/SCID mice of pancreatic cancer xenografts (6 weeks of age)
Dosage:

10 and 20 mg/kg
Administration:

Intraperitoneal administration; 1-9 days (10 mg/kg), 10-44 days (20 mg/kg)
Result:

Delayed growth of the tumors, and no systemic toxicity.

Chemical Information

CAS. Nr. 878581-60-3
Appearance Solid
Molecular Weight 250.26
Formel C₁₄H₁₀N₄O
Color Light brown to brown
SMILES

O=C(C1=NC=CN=C1)NC2=CC=CC3=CC=CN=C32
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : ≥ 16.67 mg/mL (66.61 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.9958 mL

19.9792 mL

39.9584 mL

5 mM

0.7992 mL

3.9958 mL

7.9917 mL

10 mM

0.3996 mL

1.9979 mL

3.9958 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Kuang Y, et, al. Induction of Genes Implicated in Stress Response and Autophagy by a Novel Quinolin-8-yl-nicotinamide QN523 in Pancreatic Cancer. J Med Chem. 2022 Apr 28;65(8):6133-6156. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.9958 mL	19.9792 mL	39.9584 mL	99.8961 mL
	5 mM	0.7992 mL	3.9958 mL	7.9917 mL	19.9792 mL
	10 mM	0.3996 mL	1.9979 mL	3.9958 mL	9.9896 mL
	15 mM	0.2664 mL	1.3319 mL	2.6639 mL	6.6597 mL
	20 mM	0.1998 mL	0.9990 mL	1.9979 mL	4.9948 mL
	25 mM	0.1598 mL	0.7992 mL	1.5983 mL	3.9958 mL
	30 mM	0.1332 mL	0.6660 mL	1.3319 mL	3.3299 mL
	40 mM	0.0999 mL	0.4995 mL	0.9990 mL	2.4974 mL
	50 mM	0.0799 mL	0.3996 mL	0.7992 mL	1.9979 mL
	60 mM	0.0666 mL	0.3330 mL	0.6660 mL	1.6649 mL

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QN523

Anti-Pancreatic Cancer Compound Library

Heterocyclic Compound Library

Cell Death Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

High-Throughput Bioactive Compound Library

Apoptosis Compound Library

Anti-Cancer Compound Library

Autophagy Compound Library

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

QN523

Anti-Pancreatic Cancer Compound Library

Heterocyclic Compound Library

Cell Death Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

High-Throughput Bioactive Compound Library

Apoptosis Compound Library

Anti-Cancer Compound Library

Autophagy Compound Library

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

QN523 Related Classifications

HY-148255 Related Classifications