S16–1029
S16–1029 is a selective and orally active butyrylcholinesterase (BChE) inhibitor with IC50s of 11.35 nM and 48.1 nM for eqBChE and hBChE, respectively. S16–1029 could cross the blood-brain barrier (BBB) and reach the central nervous system (CNS). S16–1029 can be used for Alzheimer's disease (AD) research.
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- CAS. Nr.: 2653349-51-8
- Formel: C23H25N7O3
- Molecular Weight:447.49
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
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Help & FAQs
Biologische Aktivität
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eqBCHE 11.35 nM (IC50) |
hBCHE 48.1 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| SH-SY5Y | IC50 |
89.77 μM
Compound: S16-1029
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Cytotoxicity against human SH-SY5Y cells assessed as survival rate incubated for 24 hrs by MTT assay
Cytotoxicity against human SH-SY5Y cells assessed as survival rate incubated for 24 hrs by MTT assay
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[PMID: 38452730] |
Chemical Information
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CAS. Nr. 2653349-51-8
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Molecular Weight 447.49
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Formel C23H25N7O3
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SMILES
O=C(CN1C(C2=NON=C2N)=NC3=C1C=CC=C3)NC4=CC=C(CCN5CCOCC5)C=C4
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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