Shield-2
Shield-2 is an efficient stabilizing ligand binding to the FKBP (F36V) protein with a dissociation constant of 29 nM. Shield-2 binds tightly to the FKBP mutants destabilizing domains and prevents degradation, thus providing small molecule regulation over intracellular protein levels.
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- CAS. Nr.: 1013621-70-9
- Formel: C35H51N3O7
- Molecular Weight:625.80
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| NIH3T3 | EC50 |
1.2 μM
Compound: shield-2
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Binding affinity to human FKBP F36V/L106P mutant-YFP fusion protein expressed in NIH3T3 cells after 24 hrs
Binding affinity to human FKBP F36V/L106P mutant-YFP fusion protein expressed in NIH3T3 cells after 24 hrs
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[PMID: 18039574] |
Chemical Information
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CAS. Nr. 1013621-70-9
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Molecular Weight 625.80
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Formel C35H51N3O7
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SMILES
COC(C=C1CC[C@H](C2=CC(OCCN3CCOCC3)=CC=C2)OC([C@H]4N(CCCC4)C(NC(CC)CC)=O)=O)=C(C=C1)OC
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Grimley JS, et al. Synthesis and analysis of stabilizing ligands for FKBP-derived destabilizing domains. Bioorg Med Chem Lett. 2008 Jan 15;18(2):759-61. [Content Brief]
[2]. Bonger KM, et al. Small-molecule displacement of a cryptic degron causes conditional protein degradation. Nat Chem Biol. 2011 Jul 3;7(8):531-7. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Shield-2 Related Classifications
HY-113646 Related Classifications
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