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Art. -Nr.: HY-182416

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slCeMM1

slCeMM1 is a selective SLC16A3 (MCT4) inhibitor. slCeMM1 inhibits lactate transport, induces intracellular lactate accumulation, reduces viability of SLC16A3-dependent cells, and inhibits growth of SLC16A3-dependent cells. slCeMM1 can be used for the research of rheumatoid arthritis and cancer.

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CAS. Nr.: 949973-22-2
Formel: C₂₀H₁₇F₃N₆O
Molecular Weight:414.38

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

slCeMM1 Chemical Structure

CAS. Nr.: 949973-22-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
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- IC₅₀ & Target
- In Vitro
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Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

MCT4

Alle Monocarboxylate Transporter Isoform-spezifische Produkte anzeigen :

In Vitro

slCeMM1 (serial dilutions; 72 h) potently and selectively inhibits viability of SLC16A3-dependent HAP1 SLC16A1^-/- cells with an IC₅₀ of 0.88 μM, while having no effect on HAP1 cells dependent on SLC16A1, SLC16A7, or SLC16A8^[1].
slCeMM1 (serial dilutions; 6 h) induces intracellular lactate accumulation in SLC16A3-dependent HAP1 SLC16A1^-/- cells with an IC₅₀ of 91 nM, confirming inhibition of SLC16A3-mediated lactate export^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 949973-22-2
Molecular Weight 414.38
Formel C₂₀H₁₇F₃N₆O
SMILES

O=C(CCC1=C(C)N2N=C(C(F)(F)F)N=C2N=C1C)NC3=CN=C4C=CC=CC4=C3
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Dvorak V, et al. Paralog-dependent isogenic cell assay cascade generates highly selective SLC16A3 inhibitors. Cell Chem Biol. 2023;30(8):953-964.e9. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biologische Aktivität
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- In Vitro
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slCeMM1

High-Throughput Bioactive Compound Library

Alle Monocarboxylate Transporter Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

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Calculators

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slCeMM1 Related Classifications

HY-182416 Related Classifications