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Art. -Nr.: HY-177666

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Solbinsiran

Name: Solbinsiran
Brand: MedChemExpress
SKU: HY-177666
Availability: PreOrder

(Synonyms: LY3561774)

Solbinsiran (LY3561774) is a GalNAc-conjugated siRNA targeting ANGPTL3. Solbinsiran mediates RNA interference against hepatic ANGPTL3 mRNA, reducing ANGPTL3 translation. Solbinsiran lowers hepatocyte ANGPTL3 mRNA and serum ANGPTL3 protein levels. Solbinsiran can be used in research on mixed dyslipidemia.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 2718150-11-7
Formel: C₆₅₃H₈₅₉O₄₁₂N₂₂₉F₁₁P₅₇S₆
Molecular Weight:20674.90

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (283 KB)

Solbinsiran Chemical Structure

CAS. Nr.: 2718150-11-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

^[1]^[2]

ANGPTL3

Alle ANGPTL Isoform-spezifische Produkte anzeigen :

In Vitro

Lipid Metabolism

Solbinsiran (LY3561774) is identified as a potent anti-ANGPTL3 siRNA in in vitro screening^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Lipid Metabolism

Solbinsiran (1 mg/kg; s.c.; single administration) reduces the expression of human ANGPTL3 mRNA in the liver of mice transiently expressing human ANGPTL3^[1].
Solbinsiran (3 mg/kg; s.c.; single dose) produces durable hepatic ANGPTL3 mRNA knockdown and reduces circulating ANGPTL3 protein levels in cynomolgus monkeys^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

CD1 (female; 6-8 weeks of age)^[1]
Dosage:

1 mg/kg
Administration:

s.c.; single dose
Result:

A single 1 mg/kg subcutaneous dose reduced human ANGPTL3 mRNA levels by 65% compared with vehicle-treated mice.

Animal Model:

Cynomolgus monkeys^[1]
Dosage:

3 mg/kg
Administration:

s.c.; single dose
Result:

A single 3 mg/kg subcutaneous dose produced mean reductions in hepatic ANGPTL3 mRNA expression of up to 72.9% and in serum ANGPTL3 protein of up to 68.6% at day 28 compared with vehicle-treated monkeys.
Hepatic mRNA knockdown remained >50% 12 weeks after the single dose.

Related Protocols :

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991			2011-05	PHASE1

Chemical Information

CAS. Nr. 2718150-11-7
Molecular Weight 20674.90
Formel C₆₅₃H₈₅₉O₄₁₂N₂₂₉F₁₁P₅₇S₆
SMILES

[Solbinsiran]
Synonyms

LY3561774
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (283 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2242 KB)

Verweise

[1]. Ray KK, et al. Effect of ANGPTL3 Inhibition With Solbinsiran in Preclinical and Early Human Studies. Journal of the American College of Cardiology. 2025 May 20;85(19):1803-1818. [Content Brief]

[2]. Dudek H, et al. Abstract 12705: Identification and Characterization of Solbinsiran, a GalNAc Conjugated siRNA Targeting Angiopoietin-Like 3. Circulation. 2023;148(Suppl 1).

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Reinheit & Dokumentation
Verweise

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Art. -Nr.:
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Solbinsiran

Alle ANGPTL Isoform-spezifische Produkte anzeigen