Art. -Nr.: HY-167208

SR-302

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SR-302, a chemical probe, is a potent and selectivity DDR/p38 inhibitor, with IC₅₀ values of 0.125, 0.023 and 0.018 μM for p38α, DDR1 and DDR2, respectively. SR-302 can be used for the research of fibrotic disorders, such as renal and pulmonary fibrosis, atherosclerosis, and various forms of cancer.

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Reinheit: 98.51%
CAS. Nr.: 2771319-74-3
Formel: C₃₂H₄₂N₆O₅S
Molecular Weight:622.78

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

SR-302 Chemical Structure

CAS. Nr.: 2771319-74-3

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

DDR1

23 nM (IC₅₀)

DDR2

18 nM (IC₅₀)

p38α

125 nM (IC₅₀)

Alle Discoidin Domain Receptor Isoform-spezifische Produkte anzeigen :

DDR1
DDR2

Alle p38 MAPK Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK-293T	IC₅₀	125 nM Compound: EUB0000712a	Cellular target engagement assay with: MAPK14 Cellular target engagement assay with: MAPK14	10.6019/CHEMBL5058541
HEK-293T	IC₅₀	18 nM Compound: EUB0000712a	Cellular target engagement assay with: DDR2 Cellular target engagement assay with: DDR2	10.6019/CHEMBL5058541
HEK-293T	IC₅₀	196 nM Compound: EUB0000712a	Cellular target engagement assay with: MAPK11 Cellular target engagement assay with: MAPK11	10.6019/CHEMBL5058541
HEK-293T	IC₅₀	23 nM Compound: EUB0000712a	Cellular target engagement assay with: DDR1 Cellular target engagement assay with: DDR1	10.6019/CHEMBL5058541

Chemical Information

CAS. Nr. 2771319-74-3
Appearance Solid
Molecular Weight 622.78
Formel C₃₂H₄₂N₆O₅S
Color White to off-white
SMILES

CS(N(CCC1)CC1NC([C@H](CCC2CCCCC2)NC(C(C=C3)=CC=C3CNC(C4=CN=C5N4C=CC=C5)=O)=O)=O)(=O)=O
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (160.57 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.6057 mL

8.0285 mL

16.0570 mL

5 mM

0.3211 mL

1.6057 mL

3.2114 mL

10 mM

0.1606 mL

0.8029 mL

1.6057 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (4.01 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (4.01 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Röhm S, et al. Development of a Selective Dual Discoidin Domain Receptor (DDR)/p38 Kinase Chemical Probe. J Med Chem. 2021 Sep 23;64(18):13451-13474. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.6057 mL	8.0285 mL	16.0570 mL	40.1426 mL
	5 mM	0.3211 mL	1.6057 mL	3.2114 mL	8.0285 mL
	10 mM	0.1606 mL	0.8029 mL	1.6057 mL	4.0143 mL
	15 mM	0.1070 mL	0.5352 mL	1.0705 mL	2.6762 mL
	20 mM	0.0803 mL	0.4014 mL	0.8029 mL	2.0071 mL
	25 mM	0.0642 mL	0.3211 mL	0.6423 mL	1.6057 mL
	30 mM	0.0535 mL	0.2676 mL	0.5352 mL	1.3381 mL
	40 mM	0.0401 mL	0.2007 mL	0.4014 mL	1.0036 mL
	50 mM	0.0321 mL	0.1606 mL	0.3211 mL	0.8029 mL
	60 mM	0.0268 mL	0.1338 mL	0.2676 mL	0.6690 mL
	80 mM	0.0201 mL	0.1004 mL	0.2007 mL	0.5018 mL
	100 mM	0.0161 mL	0.0803 mL	0.1606 mL	0.4014 mL

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SR-302

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Lactylation Compound Library

Alle Discoidin Domain Receptor Isoform-spezifische Produkte anzeigen

Alle p38 MAPK Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

SR-302 Related Classifications

HY-167208 Related Classifications