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SSGJ-707

(Synonyms: PF-08634404)
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Based on 1 Customer Validation

SSGJ-707 (PF-08634404) is a bispecific antibody targeting VEGF and PD-1. SSGJ-707 exerts dual anti-tumor effects by neutralizing VEGF and blocking the PD-1 signaling pathway. SSGJ-707 can be combined with platinum-based chemotherapy to inhibit advanced non-small cell lung cancer (NSCLC), and its inhibitory effect is not limited by PD-L1 expression levels. In the HARMONi-2 trial, the objective response rate of SSGJ-707 correlates with the PD-L1 tumor proportion score, and the incidence of grade ≥3 adverse events is comparable to that of Inetetamab (HY-P99969). SSGJ-707 is being extensively investigated for a variety of malignancies including advanced NSCLC, colorectal cancer and small cell lung cancer.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

  • Reinheit: ≥99.0%
  • Molecular Weight:241.16 kDa
  • Speicherung:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for SSGJ-707
  • Experimental Validation Results for SSGJ-707
  • Experimental Validation Results for SSGJ-707
  • Experimental Validation Results for SSGJ-707
  • Experimental Validation Results for SSGJ-707
  • SSGJ-707 Chemical Structure
    SSGJ-707 Chemical Structure
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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Finden Sie Ihren Händler vor Ort Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    Human IgG4

  • 1/16

    Flow Cytometry analysis of Hela cells labelling PD-1 (red) with SSGJ-707 (anti-PD-1) (HY-P991628). Cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 (S228P) kappa (HY-P99003, blue) was used as the isotype control.

  • 1/16

    Flow Cytometry analysis of K562 cells labelling VEGF (red) with SSGJ-707 (HY-P991628). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 (S228P) kappa (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • 1/16

    Immobilized Human PD-1 Protein, His tag can bind SSGJ-707. The EC50 for this effect is 43.15 ng/mL.

  • 1/16

    Immobilized rhVEGF can bind SSGJ-707. The EC50 for this effect is 74.03 ng/mL.

  • SSGJ-707 Chemical Structure
    1/16
  • SSGJ-707
  • Flow Cytometry analysis of Hela cells labelling PD-1 (red) with SSGJ-707 (anti-PD-1) (HY-P991628). Cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 (S228P) kappa (HY-P99003, blue) was used as the isotype control.
  • Flow Cytometry analysis of K562 cells labelling VEGF (red) with SSGJ-707 (HY-P991628). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 (S228P) kappa (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
  • Immobilized Human PD-1 Protein, His tag can bind SSGJ-707. The EC50 for this effect is 43.15 ng/mL.
  • Immobilized rhVEGF can bind SSGJ-707. The EC50 for this effect is 74.03 ng/mL.