2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. Inetetamab

Inetetamab is a monoclonal antibody binding to domain IV of HER2 receptor. Inetetamab alone or together with tyrosine kinase inhibitors has antitumor activities.

For research use only. We do not sell to patients.

Inetetamab Chemical Structure

Inetetamab Chemical Structure

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5 mg USD 910 In-stock
10 mg USD 1500 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Inetetamab is a monoclonal antibody binding to domain IV of HER2 receptor. Inetetamab alone or together with tyrosine kinase inhibitors has antitumor activities[1][2].

IC50 & Target[1]

HER2

 

In Vivo

Inetetamab (20 mg/kg, i.p.) shows antitumor effects in the JIMT-1 xenograft mouse model[2].
Inetetamab (20 mg/kg, i.p.) together with Pyrotinib or Cyclophosphamide also has distinct antitumor effects in JIMT-1 and NCI-N87 xenograft mouse model[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: JIMT-1 xenograft mouse model[2]
Dosage: 20 mg/kg, or together with Pyrotinib (20 mg/kg, p.o.) or Cyclophosphamide (10 mg/kg, p.o.)
Administration: i.p, twice a week
Result: Inhibited tumor growth with a tumor growth inhibition (TGI) rate of approximately 40%, and induces a stronger synergistic antitumor effect with Pyrotinib or Cyclophosphamide.
Clinical Trial
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Inetetamab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 96.54%

COA (231 KB)

Handling Instructions (2659 KB)
References
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Inetetamab Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

InetetamabEGFREpidermal growth factor receptorErbB-1HER1Cancerbreast cancergastric cancerJIMT-1NCI-N87monoclonal antibodyInhibitorinhibitorinhibit

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