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Cat. No.: HY-110253

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18A

(Synonyms: HIV-1 inhibitor 18A)

18A (HIV-1 inhibitor 18A) is a reversible broad-spectrum HIV-1 inhibitor. 18A exhibits broad inhibitory activity against multiple HIV-1 strains by blocking the function of Env.

For research use only. We do not sell to patients.

CAS No.: 331261-50-8
Formula: C₁₄H₁₁N₅O₂S
Molecular Weight:313.33

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

18A Chemical Structure

CAS No.: 331261-50-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

18A (HIV-1 inhibitor 18A) is a reversible broad-spectrum HIV-1 inhibitor. 18A exhibits broad inhibitory activity against multiple HIV-1 strains by blocking the function of Env^[1].

IC₅₀ & Target

HIV-1^[1].

All HIV Isoforms :

In Vitro

18A (0.01-10 µM; 40-44 h) shows specific inhibition of HIV-1JR-FL infection of human PBMCs (IC₅₀ = 0.4 μM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

PBMCs
Concentration:

0.01-10 µM
Incubation Time:

40-44 h
Result:

Inhibited infection of HIV-1JR-FL, with an IC₅₀ value of 0.4 μM.

Chemical Information

CAS No. 331261-50-8
Molecular Weight 313.33
Formula C₁₄H₁₁N₅O₂S
SMILES

OC(C=C1)=CC=C1/C=N/NC(NC2=CC=CC3=NSN=C23)=O
Synonyms

HIV-1 inhibitor 18A
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Herschhorn A, et al. A broad HIV-1 inhibitor blocks envelope glycoprotein transitions critical for entry. Nat Chem Biol. 2014 Oct;10(10):845-52. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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18A

All HIV Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

18A Related Classifications

HY-110253 Related Classifications