BTR2004
Based on 1 Customer Validation
BTR2004 is a selective BET family (BRD2/3/4) protein PROTAC degrader. BTR2004 forms a ternary complex with BRD proteins and KLHL20, inducing ubiquitination and proteasomal degradation through the UPS pathway. BTR2004 is promising for research of PC3 prostate cancer and MDA-MB-231 breast cancer cell lines.
(Pink: BET ligand (HY-161125); Blue: Ligands for E3 Ligase ligand (HY-172563); Black: linker (HY-W015236)).
For research use only. We do not sell to patients.
- Purity: 99.86%
- CAS No.: 3093583-69-5
- Formula: C54H66ClN13O11S3
- Molecular Weight:1204.83
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All PROTACs Isoforms
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Biological Activity
Chemical Information
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CAS No. 3093583-69-5
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Appearance Solid
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Molecular Weight 1204.83
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Formula C54H66ClN13O11S3
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Color White to off-white
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SMILES
CC1=NN=C2N1C3=C(C(C)=C(C)S3)C(C4=CC=C(Cl)C=C4)=N[C@H]2CC(NCC(NCC(NCC(N[C@H](C(N5[C@H](C(N[C@@H](CC(O)=O)C(N[C@@H](CC(C)C)C(N[C@H](C(N)=O)CSC6)=O)=O)=O)CCC5)=O)CSCC7=CC=CC6=C7)=O)=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : ≥ 100 mg/mL (83.00 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
[1]. Farrell BM, et al. A synthetic KLHL20 ligand to validate CUL3KLHL20 as a potent E3 ligase for targeted protein degradation. Genes Dev. 2022 Sep 1;36(17-18):1031-1042. [Content Brief]
[2]. Fechtmeyer PH, et al. Temporal and Spatial Characterization of CUL3KLHL20-driven Targeted Degradation of BET family, BRD Proteins by the Macrocycle-based Degrader BTR2004. bioRxiv [Preprint]. 2024 Dec 7:2024.12.07.627262. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 0.8300 mL | 4.1500 mL | 8.2999 mL | 20.7498 mL |
| 5 mM | 0.1660 mL | 0.8300 mL | 1.6600 mL | 4.1500 mL | |
| 10 mM | 0.0830 mL | 0.4150 mL | 0.8300 mL | 2.0750 mL | |
| 15 mM | 0.0553 mL | 0.2767 mL | 0.5533 mL | 1.3833 mL | |
| 20 mM | 0.0415 mL | 0.2075 mL | 0.4150 mL | 1.0375 mL | |
| 25 mM | 0.0332 mL | 0.1660 mL | 0.3320 mL | 0.8300 mL | |
| 30 mM | 0.0277 mL | 0.1383 mL | 0.2767 mL | 0.6917 mL | |
| 40 mM | 0.0207 mL | 0.1037 mL | 0.2075 mL | 0.5187 mL | |
| 50 mM | 0.0166 mL | 0.0830 mL | 0.1660 mL | 0.4150 mL | |
| 60 mM | 0.0138 mL | 0.0692 mL | 0.1383 mL | 0.3458 mL | |
| 80 mM | 0.0104 mL | 0.0519 mL | 0.1037 mL | 0.2594 mL |
BTR2004 Related Classifications
HY-172562 Related Classifications
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