CPP12
Based on 1 Customer Validation
CPP12 is a small, amphipathic, cyclic cell-penetrating peptide (CPP). CPP12 binds directly to plasma membrane phospholipids, enters mammalian cells via endocytosis, and then efficiently escapes from endosomes. CPP12 can be used for the intracellular delivery of drugs and chemical probes.
For research use only. We do not sell to patients.
- Purity: 99.10%
- CAS No.: 1831064-62-0
- Formula: C60H85N21O9
- Molecular Weight:1244.45
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
CPP12 (5 μM; 2 h) exhibits high cytosolic entry efficiency in HeLa cells, serving as a 100% activity reference; its efficiency is reduced ~25-fold when serum concentration increases from 1% to 10% FBS[1].
CPP12 (5 μM; 2 h) enters HeLa cells primarily via endocytosis followed by endosomal escape[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1831064-62-0
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Appearance Solid
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Molecular Weight 1244.45
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Formula C60H85N21O9
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Color White to off-white
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Sequence
Cyclo(Phe-{d-Phe}-{2-Nal}-Arg-{d-Arg}-Arg-{d-Arg}-Gln)
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Sequence Shortening
Cyclo(F-{d-Phe}-{2-Nal}-R-{d-Arg}-R-{d-Arg}-Q)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL (80.36 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (286 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 0.8036 mL | 4.0178 mL | 8.0357 mL | 20.0892 mL |
| 5 mM | 0.1607 mL | 0.8036 mL | 1.6071 mL | 4.0178 mL | |
| 10 mM | 0.0804 mL | 0.4018 mL | 0.8036 mL | 2.0089 mL | |
| 15 mM | 0.0536 mL | 0.2679 mL | 0.5357 mL | 1.3393 mL | |
| 20 mM | 0.0402 mL | 0.2009 mL | 0.4018 mL | 1.0045 mL | |
| 25 mM | 0.0321 mL | 0.1607 mL | 0.3214 mL | 0.8036 mL | |
| 30 mM | 0.0268 mL | 0.1339 mL | 0.2679 mL | 0.6696 mL | |
| 40 mM | 0.0201 mL | 0.1004 mL | 0.2009 mL | 0.5022 mL | |
| 50 mM | 0.0161 mL | 0.0804 mL | 0.1607 mL | 0.4018 mL | |
| 60 mM | 0.0134 mL | 0.0670 mL | 0.1339 mL | 0.3348 mL | |
| 80 mM | 0.0100 mL | 0.0502 mL | 0.1004 mL | 0.2511 mL |
CPP12 Related Classifications
HY-P10649 Related Classifications
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