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Cat. No.: HY-165375

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Plenolin

Plenolin is an anticancer agent. Plenolin exhibits inhibitory activity against human epidermoid carcinoma cells. Plenolin shows in vivo antitumor activity against ascites carcinosarcoma and lymphocytic leukemia in rodent models. Plenolin can be used for research related to ascites tumors and leukemia.

For research use only. We do not sell to patients.

CAS No.: 34257-95-9
Formula: C₁₅H₂₀O₄
Molecular Weight:264.32

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Plenolin Chemical Structure

CAS No.: 34257-95-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
HEp-2	ED₅₀	0.81 μg/mL Compound: 12	Cytotoxicity against human Hep2 cells assessed as growth inhibition by microtiter method Cytotoxicity against human Hep2 cells assessed as growth inhibition by microtiter method	[PMID: 671468]
HEp-2	ED₅₀	0.814 μg/mL Compound: 3	Cytotoxicity against human Hep2 cells Cytotoxicity against human Hep2 cells	[PMID: 845864]
HepG2	ED₅₀	0.8 μg/mL Compound: 6	Cytotoxicity against human HepG2 cells Cytotoxicity against human HepG2 cells	[PMID: 20187635]

In Vitro

Plenolin (Compound 3) exhibits a cytotoxic ED₅₀ of 0.814 μg/mL against H.Ep.-2 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Plenolin (33.3 mg/kg; i.p.; once daily for 7 days) exerts 100.0% inhibitory effect on the growth of Ehrlich ascites carcinoma in male CF₁ mice, completely suppresses ascites accumulation, and the survival rate of treated mice reaches 100% on day 7^[1].
For male rats bearing Walker 256 ascitic carcinosarcoma, the T/C value of mean survival days is 207 when treated with Plenolin at 2.5 mg/kg via i.p. administration^[1].
Plenolin (25 mg/kg; i.p.) results in a T/C value of 134 for mean survival days in male DBA/2 mice inoculated with P388 leukemia^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

CF₁ (male, ~30 g, implanted with 10⁶ Ehrlich ascites carcinoma cells)^[1]
Dosage:

33.3 mg/kg/day
Administration:

i.p.; daily
Result:

Achieved 100.0% inhibition of tumor growth.
Reduced ascites-crit to 0.
Reduced total ascites fluid volume to 0.0 mL.
Ensured 100% survival of 5 treated mice to day 7.

Chemical Information

CAS No. 34257-95-9
Molecular Weight 264.32
Formula C₁₅H₂₀O₄
SMILES

C[C@@]12[C@]([C@H](C)C[C@@]3([C@]([C@@H]1O)([C@H](C)C(=O)O3)[H])[H])(C=CC2=O)[H]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Hall IH, et al. Antitumor agents. 21. A proposed mechanism for inhibition of cancer growth by tenulin and helenalin and related cyclopentenones. J Med Chem. 1977;20(3):333-337. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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