(S)-4C3HPG
(S)-4C3HPG ((S)-4-Carboxy-3-hydroxyphenylglycine) is an antagonist of mGluR1a and an agonist of mGluR2. (S)-4C3HPG has the anticonvulsant activity and protects against audiogenic seizures in DBA/2 mice.
For research use only. We do not sell to patients.
- CAS No.: 85148-82-9
- Formula: C9H9NO5
- Molecular Weight:211.17
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Description
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | EC50 |
>100 μM
Compound: 21
|
Stimulation of [3H]phosphatidylinositol accumulation by rat Metabotropic glutamate receptor 4 co-expressed with Gqi9 protein in HEK 293 cells; Inactive
Stimulation of [3H]phosphatidylinositol accumulation by rat Metabotropic glutamate receptor 4 co-expressed with Gqi9 protein in HEK 293 cells; Inactive
|
[PMID: 15801843] |
| HEK293 | IC50 |
40 μM
Compound: 34
|
Inhibitory activity against Metabotropic glutamate receptor 1 in the rat LLC-PK1/HEK 293 cells
Inhibitory activity against Metabotropic glutamate receptor 1 in the rat LLC-PK1/HEK 293 cells
|
[PMID: 10229625] |
In Vitro
The mGluR1a/mGluR2 receptor refers to a subtype of metabolite glutamate receptor, belonging to the G protein-coupled receptor superfamily. mGluR1a is mainly distributed on the postsynaptic membrane of the central nervous system, regulating synaptic plasticity, while mGluR2 acts as a presynaptic autoreceptor, negatively inhibiting glutamate release. Both are important targets for drug development in neurological diseases.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
-
CAS No. 85148-82-9
-
Molecular Weight 211.17
-
Formula C9H9NO5
-
SMILES
OC1=C(C(O)=O)C=CC([C@H](N)C(O)=O)=C1
-
Synonyms
(S)-4-Carboxy-3-hydroxyphenylglycine
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. C Thomsen, et al. (S)-4-carboxy-3-hydroxyphenylglycine, an antagonist of metabotropic glutamate receptor (mGluR) 1a and an agonist of mGluR2, protects against audiogenic seizures in DBA/2 mice. J Neurochem. 1994 Jun;62(6):2492-5. [Content Brief]
[2]. Thomsen C, et al. (S)-4-carboxy-3-hydroxyphenylglycine, an antagonist of metabotropic glutamate receptor (mGluR) 1a and an agonist of mGluR2, protects against audiogenic seizures in DBA/2 mice. J Neurochem. 1994 Jun;62(6):2492-5. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(S)-4C3HPG Related Classifications
HY-100840 Related Classifications
Powered by Bioz