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Cat. No.: HY-146890

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ATX inhibitor 17

ATX inhibitor 17 is a potent ATX inhibitor with an IC₅₀ of 0.019 μM. ATX inhibitor 17 shows excellent anti-proliferative activities in breast cancer cells.

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CAS No.: 2750152-64-6
화학식: C₂₉H₂₉F₅N₈S
분자량:616.65

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

ATX inhibitor 17 Chemical Structure

CAS No.: 2750152-64-6

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

ATX inhibitor 17 is a potent ATX inhibitor with an IC₅₀ of 0.019 μM. ATX inhibitor 17 shows excellent anti-proliferative activities in breast cancer cells^[1].

IC₅₀ & Target

IC₅₀: 0.019 µM (ATX)^[1]

All Phosphodiesterase (PDE) Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	13.4 μM Compound: 25a	Antiproliferative activity against human A549 cells measured after 72 hrs by MTT assay Antiproliferative activity against human A549 cells measured after 72 hrs by MTT assay	[PMID: 32535330]
MCF7	IC₅₀	1.01 μM Compound: 25a	Antiproliferative activity against human MCF7 cells measured after 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells measured after 72 hrs by MTT assay	[PMID: 32535330]
MDA-MB-231	IC₅₀	0.79 μM Compound: 25a	Antiproliferative activity against human MDA-MB-231 cells measured after 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells measured after 72 hrs by MTT assay	[PMID: 32535330]
NCI-H2228	IC₅₀	>15 μM Compound: 25a	Antiproliferative activity against human NCI-H2228 cells measured after 72 hrs by MTT assay Antiproliferative activity against human NCI-H2228 cells measured after 72 hrs by MTT assay	[PMID: 32535330]

In Vitro

ATX inhibitor 17 (compound 25a) (0-15 μM; 72 h) shows excellent anti-proliferative activities in breast cancer cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

MCF7, MDA-MB-231, A549, H2228 cells
Concentration:

0-15 µM
Incubation Time:

72 h
Result:

Showed excellent antiproliferative effects with IC₅₀s of 1.01, 0.79, 13.40, >15 µM for MCF7, MDA-MB-231, A549, H2228 cells, respectively.

Chemical Information

CAS No. 2750152-64-6
분자량 616.65
화학식 C₂₉H₂₉F₅N₈S
SMILES

CC1=C(C2=CC(N3CCN(CC3)CCN(C)C)=C(C=C2N1)F)/C(C(F)(F)F)=N/NC4=NC(C5=CC=C(C=C5)F)=C(S4)C#N
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lei H,et al. Structure guided design of potent indole-based ATX inhibitors bearing hydrazone moiety with tumor suppression effects. Eur J Med Chem. 2020 Sep 1;201:112456. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

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수량:
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ATX inhibitor 17

All Phosphodiesterase (PDE) Isoforms