ATX inhibitor 17
ATX inhibitor 17 is a potent ATX inhibitor with an IC50 of 0.019 μM. ATX inhibitor 17 shows excellent anti-proliferative activities in breast cancer cells.
For research use only. We do not sell to patients.
- CAS No.: 2750152-64-6
- Formula: C29H29F5N8S
- Molecular Weight:616.65
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
IC50: 0.019 µM (ATX)[1]
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
13.4 μM
Compound: 25a
|
Antiproliferative activity against human A549 cells measured after 72 hrs by MTT assay
Antiproliferative activity against human A549 cells measured after 72 hrs by MTT assay
|
[PMID: 32535330] |
| MCF7 | IC50 |
1.01 μM
Compound: 25a
|
Antiproliferative activity against human MCF7 cells measured after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells measured after 72 hrs by MTT assay
|
[PMID: 32535330] |
| MDA-MB-231 | IC50 |
0.79 μM
Compound: 25a
|
Antiproliferative activity against human MDA-MB-231 cells measured after 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells measured after 72 hrs by MTT assay
|
[PMID: 32535330] |
| NCI-H2228 | IC50 |
>15 μM
Compound: 25a
|
Antiproliferative activity against human NCI-H2228 cells measured after 72 hrs by MTT assay
Antiproliferative activity against human NCI-H2228 cells measured after 72 hrs by MTT assay
|
[PMID: 32535330] |
ATX inhibitor 17 (compound 25a) (0-15 μM; 72 h) shows excellent anti-proliferative activities in breast cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:MCF7, MDA-MB-231, A549, H2228 cells
-
Concentration:0-15 µM
-
Incubation Time:72 h
-
Result:Showed excellent antiproliferative effects with IC50s of 1.01, 0.79, 13.40, >15 µM for MCF7, MDA-MB-231, A549, H2228 cells, respectively.
Chemical Information
-
CAS No. 2750152-64-6
-
Molecular Weight 616.65
-
Formula C29H29F5N8S
-
SMILES
CC1=C(C2=CC(N3CCN(CC3)CCN(C)C)=C(C=C2N1)F)/C(C(F)(F)F)=N/NC4=NC(C5=CC=C(C=C5)F)=C(S4)C#N
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ATX inhibitor 17 Related Classifications
HY-146890 Related Classifications
Powered by Bioz