Tavilermide
Based on 2 publication(s) in Google Scholar
Tavilermide is a selective, partial agonist of TrkA, or a nerve growth factor (NGF) mimetic.
For research use only. We do not sell to patients.
- Purity: 99.57%
- CAS No.: 263251-78-1
- Formula: C24H32N6O11
- Molecular Weight:580.54
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Tavilermide
More
Biological Activity
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TrkA |
Tavilermide (MIM-D3) is a tyrosine kinase TrkA receptor agonist, which can be used to treat dry eye.Tavilermide is a proteolytically stable, cyclic peptidomimetic that has been shown to be a partial TrkA receptor agonist. Tavilermide demonstrates activities similar to NGF (but does not bind to the p75NTR receptor) and can potentiate the effects of suboptimal concentrations of NGF[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 263251-78-1
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Appearance Solid
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Molecular Weight 580.54
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Formula C24H32N6O11
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Color White to off-white
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SMILES
O=C(O)CC[C@H](N1)C(N[C@@H](CCCCN)C(N[C@H](C(NCC(O)=O)=O)CCOC2=CC=C([N+]([O-])=O)C=C2C1=O)=O)=O
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Synonyms
MIM-D3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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Brain
Ultrasound delivery of a TrkA agonist confers neuroprotection to Alzheimer-associated pathologies. [Abstract]2022 Aug 27;145(8):2806-2822. PMID: 34919633 -
Nanoscale
Synergistically dual-functional nano eye-drops for simultaneous anti-inflammatory and anti-oxidative treatment of dry eye disease. [Abstract]2019 Mar 21;11(12):5580-5594. PMID: 30860532
Solvent & Solubility
NH4OH : 50 mg/mL (86.13 mM; ultrasonic and adjust pH to 10 with NH4OH)
H2O : 2 mg/mL (3.45 mM; Need ultrasonic)
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 4.17 mg/mL (7.18 mM); Clear solution; Need ultrasonic and warming and heat to 60°C
Add each solvent one by one: 50% PEG300 50% Saline
Solubility: 25 mg/mL (43.06 mM); Suspended solution; Need ultrasonic
Add each solvent one by one: 0.5% CMC-Na/saline water
Solubility: 10 mg/mL (17.23 mM); Suspended solution; Need ultrasonic
Purity & Documentation
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Data Sheet (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / NH4OH | 1 mM | 1.7225 mL | 8.6127 mL | 17.2253 mL | 43.0634 mL |
| NH4OH | 5 mM | 0.3445 mL | 1.7225 mL | 3.4451 mL | 8.6127 mL |
| 10 mM | 0.1723 mL | 0.8613 mL | 1.7225 mL | 4.3063 mL | |
| 15 mM | 0.1148 mL | 0.5742 mL | 1.1484 mL | 2.8709 mL | |
| 20 mM | 0.0861 mL | 0.4306 mL | 0.8613 mL | 2.1532 mL | |
| 25 mM | 0.0689 mL | 0.3445 mL | 0.6890 mL | 1.7225 mL | |
| 30 mM | 0.0574 mL | 0.2871 mL | 0.5742 mL | 1.4354 mL | |
| 40 mM | 0.0431 mL | 0.2153 mL | 0.4306 mL | 1.0766 mL | |
| 50 mM | 0.0345 mL | 0.1723 mL | 0.3445 mL | 0.8613 mL | |
| 60 mM | 0.0287 mL | 0.1435 mL | 0.2871 mL | 0.7177 mL | |
| 80 mM | 0.0215 mL | 0.1077 mL | 0.2153 mL | 0.5383 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Tavilermide Related Classifications
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