JCP174
JCP174 is an inhibitor of palmitoyl protein thioesterase-1 (TgPPT1), a depalmitoylase in the parasite T. gondii. JCP174 is also an inhibitor of porcine pancreatic elastase and human leukocyte elastase.
For research use only. We do not sell to patients.
- CAS No.: 126062-19-9
- Formula: C12H12ClNO3
- Molecular Weight:253.68
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Chemical Information
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CAS No. 126062-19-9
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Molecular Weight 253.68
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Formula C12H12ClNO3
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SMILES
O=C1OC(OCCC)=C(C2=C1C=C(C=C2)N)Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Child MA, et al. Small-molecule inhibition of a depalmitoylase enhances Toxoplasma host-cell invasion. Nat Chem Biol. 2013 Oct;9(10):651-6. [Content Brief]
[2]. Powers JC, et al. Reaction of porcine pancreatic elastase with 7-substituted 3-alkoxy-4-chloroisocoumarins: design of potent inhibitors using the crystal structure of the complex formed with 4-chloro-3-ethoxy-7-guanidinoisocoumarin. Biochemistry. 1990 Mar 27;29(12):3108-18. [Content Brief]
[3]. Kerrigan JE, et al. Mechanism-based isocoumarin inhibitors for human leukocyte elastase. Effect of the 7-amino substituent and 3-alkoxy group in 3-alkoxy-7-amino-4-chloroisocoumarins on inhibitory potency. J Med Chem. 1995 Feb 3;38(3):544-52. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JCP174 Related Classifications
HY-118621 Related Classifications
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