NCL1
NCL1 is a phenylcyclopropylamine (PCPA)-based Lysine-specific demethylase 1 (LSD1) inhibitor. NCL1 selectively inhibits LSD1 in preference to LSD2, with IC50 values of 2.5 and 26 μM for LSD1 and LSD2, respectively.
For research use only. We do not sell to patients.
- CAS No.: 1196119-03-5
- Formula: C27H29N3O3
- Molecular Weight:443.54
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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LSD1 2.5 ± 0.5 μM (IC50) |
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | GI50 |
6 μM
Compound: 31
|
Growth inhibition of human HCT116 cells after 48 hrs by MTT assay
Growth inhibition of human HCT116 cells after 48 hrs by MTT assay
|
[PMID: 22975593] |
| HCT-116 | GI50 |
6 μM
Compound: NCL-1
|
Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay
Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay
|
[PMID: 32931269] |
| HeLa | GI50 |
13 μM
Compound: 4; NCL1
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Antiproliferative activity against human HeLa cells assessed as growth inhibition after 48 h by MTT assay
Antiproliferative activity against human HeLa cells assessed as growth inhibition after 48 h by MTT assay
|
10.1039/C4MD00330F |
| HeLa | GI50 |
6 μM
Compound: 31
|
Growth inhibition of human HeLa cells after 48 hrs by MTT assay
Growth inhibition of human HeLa cells after 48 hrs by MTT assay
|
[PMID: 22975593] |
| HeLa | GI50 |
6 μM
Compound: NCL-1
|
Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
|
[PMID: 32931269] |
| KYSE-150 cell line | GI50 |
6 μM
Compound: 31
|
Growth inhibition of human KYSE-150 cells after 48 hrs by MTT assay
Growth inhibition of human KYSE-150 cells after 48 hrs by MTT assay
|
[PMID: 22975593] |
| KYSE-150 cell line | GI50 |
6 μM
Compound: NCL-1
|
Antiproliferative activity against human KYSE150 cells after 48 hrs by MTT assay
Antiproliferative activity against human KYSE150 cells after 48 hrs by MTT assay
|
[PMID: 32931269] |
| PC-3 | GI50 |
6 μM
Compound: 31
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Growth inhibition of human PC3 cells after 48 hrs by MTT assay
Growth inhibition of human PC3 cells after 48 hrs by MTT assay
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[PMID: 22975593] |
| PC-3 | GI50 |
6 μM
Compound: NCL-1
|
Antiproliferative activity against human PC-3 cells after 48 hrs by MTT assay
Antiproliferative activity against human PC-3 cells after 48 hrs by MTT assay
|
[PMID: 32931269] |
| SH-SY5Y | GI50 |
27 μM
Compound: 4; NCL1
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Antiproliferative activity against human SH-SY5Y cells assessed as growth inhibition after 48 h by MTT assay
Antiproliferative activity against human SH-SY5Y cells assessed as growth inhibition after 48 h by MTT assay
|
10.1039/C4MD00330F |
| SH-SY5Y | GI50 |
6 μM
Compound: 31
|
Growth inhibition of human SH-SY5Y cells after 48 hrs by MTT assay
Growth inhibition of human SH-SY5Y cells after 48 hrs by MTT assay
|
[PMID: 22975593] |
| SH-SY5Y | GI50 |
6 μM
Compound: NCL-1
|
Antiproliferative activity against human SH-SY5Y cells after 48 hrs by MTT assay
Antiproliferative activity against human SH-SY5Y cells after 48 hrs by MTT assay
|
[PMID: 32931269] |
Chemical Information
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CAS No. 1196119-03-5
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Molecular Weight 443.54
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Formula C27H29N3O3
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SMILES
O=C(N[C@H](C(NCC1=CC=CC=C1)=O)CCOC2=CC=CC(C3C(N)C3)=C2)C4=CC=CC=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NCL1 Related Classifications
HY-12645 Related Classifications
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