Rosonabant
Based on 1 Customer Validation
Rosonabant is a selective antagonist for cannabinoid receptor (CB1 receptor), which reduces body weight and improves improves the risk of obesity-related cardiovascular metabolic diseases. Rosonabant exhibits adverse side effect, such as nausea and mental disorder.
For research use only. We do not sell to patients.
- Purity : 99.68%
- CAS No.: 861151-12-4
- Formula: C21H21Cl3N4O
- Molecular Weight:451.78
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Storage:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Chemical Information
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CAS No. 861151-12-4
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Appearance Solid
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Molecular Weight 451.78
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Formula C21H21Cl3N4O
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Color White to off-white
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SMILES
ClC1=CC=C(C2CC(C(NN3CCCCC3)=O)=NN2C4=CC=C(Cl)C=C4Cl)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
In Vitro:
DMSO : 60 mg/mL (132.81 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocols
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Research Protocol for Metabolic Diseases
AMP-activated protein kinase, AMPK, is a conserved cellular energy sensor that responds to reduced cellular energy status and coordinates metabolism by increasing ATP-generating catabolic pathways while suppressing ATP-consuming anabolic processes. In metabolic disease research, the AMPK pathway is experimentally relevant because it regulates hepatic lipid synthesis, fatty acid oxidation, glucose production, skeletal-muscle glucose disposal, mTORC1-linked biosynthesis, autophagy, mitochondrial homeostasis, and whole-body energy balance. The central pathway logic is that energy stress, metformin, exercise-like stimulation, or direct AMPK activators increase AMPKα Thr172 phosphorylation and downstream substrate phosphorylation, including ACC and RAPTOR. Phosphorylation of ACC suppresses lipogenesis and supports fatty acid oxidation, whereas phosphorylation of RAPTOR suppresses mTORC1 signaling and links cellular energy status to growth and protein synthesis control. The pathway is linked
Purity & Documentation
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Data Sheet (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2135 mL | 11.0673 mL | 22.1347 mL | 55.3367 mL |
| 5 mM | 0.4427 mL | 2.2135 mL | 4.4269 mL | 11.0673 mL | |
| 10 mM | 0.2213 mL | 1.1067 mL | 2.2135 mL | 5.5337 mL | |
| 15 mM | 0.1476 mL | 0.7378 mL | 1.4756 mL | 3.6891 mL | |
| 20 mM | 0.1107 mL | 0.5534 mL | 1.1067 mL | 2.7668 mL | |
| 25 mM | 0.0885 mL | 0.4427 mL | 0.8854 mL | 2.2135 mL | |
| 30 mM | 0.0738 mL | 0.3689 mL | 0.7378 mL | 1.8446 mL | |
| 40 mM | 0.0553 mL | 0.2767 mL | 0.5534 mL | 1.3834 mL | |
| 50 mM | 0.0443 mL | 0.2213 mL | 0.4427 mL | 1.1067 mL | |
| 60 mM | 0.0369 mL | 0.1845 mL | 0.3689 mL | 0.9223 mL | |
| 80 mM | 0.0277 mL | 0.1383 mL | 0.2767 mL | 0.6917 mL | |
| 100 mM | 0.0221 mL | 0.1107 mL | 0.2213 mL | 0.5534 mL |
Rosonabant Related Classifications
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