Axl-IN-8
Axl-IN-8 (NO.1) is a potent AXL inhibitor, with an IC50 of <1 nM. Axl-IN-8 also inhibits c-MET, with an IC50 of 1-10 nM. Axl-IN-8 shows anti-proliferative activity against BaF3/TEL-AXL, MKN45, and EBC-1 cells, with IC50 values of <10, 226.6 and 120.3 nM, respectively.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2231424-62-5
- 分子式: C31H29FN6O3
- 分子量:552.60
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
|
Axl |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BaF3 | IC50 |
<1 nM
Compound: 9g
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Antiproliferative activity against mouse BaF3 stably expressing human TEL-AXL incubated for 72 hrs
Antiproliferative activity against mouse BaF3 stably expressing human TEL-AXL incubated for 72 hrs
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[PMID: 33957388] |
| MKN-45 | IC50 |
247.9 nM
Compound: 9g
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Antiproliferative activity against human MKN-45 cells incubated for 72 hrs
Antiproliferative activity against human MKN-45 cells incubated for 72 hrs
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[PMID: 33957388] |
化学情報
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CAS 番号 2231424-62-5
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分子量 552.60
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分子式 C31H29FN6O3
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SMILES
CN1C=C(C2=C1N=CN=C2N)C3=CC=C(C=C3)NC(C4=CN(C=C(C4=O)C5=CC=C(C=C5)F)CC6CCOCC6)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Axl-IN-8 関連分類
HY-147575 関連分類
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