Axl-IN-8
Axl-IN-8 (NO.1) is a potent AXL inhibitor, with an IC50 of <1 nM. Axl-IN-8 also inhibits c-MET, with an IC50 of 1-10 nM. Axl-IN-8 shows anti-proliferative activity against BaF3/TEL-AXL, MKN45, and EBC-1 cells, with IC50 values of <10, 226.6 and 120.3 nM, respectively.
For research use only. We do not sell to patients.
- CAS No.: 2231424-62-5
- Formula: C31H29FN6O3
- Molecular Weight:552.60
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Axl |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BaF3 | IC50 |
<1 nM
Compound: 9g
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Antiproliferative activity against mouse BaF3 stably expressing human TEL-AXL incubated for 72 hrs
Antiproliferative activity against mouse BaF3 stably expressing human TEL-AXL incubated for 72 hrs
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[PMID: 33957388] |
| MKN-45 | IC50 |
247.9 nM
Compound: 9g
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Antiproliferative activity against human MKN-45 cells incubated for 72 hrs
Antiproliferative activity against human MKN-45 cells incubated for 72 hrs
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[PMID: 33957388] |
Chemical Information
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CAS No. 2231424-62-5
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Molecular Weight 552.60
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Formula C31H29FN6O3
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SMILES
CN1C=C(C2=C1N=CN=C2N)C3=CC=C(C=C3)NC(C4=CN(C=C(C4=O)C5=CC=C(C=C5)F)CC6CCOCC6)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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