2. Protein Tyrosine Kinase/RTK
  3. TAM Receptor c-Met/HGFR
  4. Axl-IN-8

Axl-IN-8 (NO.1) is a potent AXL inhibitor, with an IC50 of <1 nM. Axl-IN-8 also inhibits c-MET, with an IC50 of 1-10 nM. Axl-IN-8 shows anti-proliferative activity against BaF3/TEL-AXL, MKN45, and EBC-1 cells, with IC50 values of <10, 226.6 and 120.3 nM, respectively.

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Axl-IN-8 Chemical Structure

Axl-IN-8 Chemical Structure

CAS No. : 2231424-62-5

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Axl-IN-8 Related Antibodies

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Description

Axl-IN-8 (NO.1) is a potent AXL inhibitor, with an IC50 of <1 nM. Axl-IN-8 also inhibits c-MET, with an IC50 of 1-10 nM. Axl-IN-8 shows anti-proliferative activity against BaF3/TEL-AXL, MKN45, and EBC-1 cells, with IC50 values of <10, 226.6 and 120.3 nM, respectively[1].

Molecular Weight

552.60

Formula

C31H29FN6O3
CAS No.
SMILES

CN1C=C(C2=C1N=CN=C2N)C3=CC=C(C=C3)NC(C4=CN(C=C(C4=O)C5=CC=C(C=C5)F)CC6CCOCC6)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Axl-IN-8 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Axl-IN-82231424-62-5TAM Receptorc-Met/HGFRTyro3AxlMerSNU-886 cellsBaF3/TEL-AXLMKN45EBC-1 cellsCancerInhibitorinhibitorinhibit

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