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Cat. No.: HY-163663

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AZ14133346

AZ14133346 (compound 36) is a potent and selective inhibitor of EGFR Exon20 insertions, with the IC₅₀ of 85 nM. AZ14133346 plays an important role in cancer research.

For research use only. We do not sell to patients.

Formula: C₂₉H₂₇N₅O₂
Molecular Weight:477.56

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

AZ14133346 Chemical Structure

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Top Publications Citing

Use of MCE Products

Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity

Description

AZ14133346 (compound 36) is a potent and selective inhibitor of EGFR Exon20 insertions, with the IC₅₀ of 85 nM. AZ14133346 plays an important role in cancer research^[1].

All EGFR Isoforms :

Chemical Information

Molecular Weight 477.56
Formula C₂₉H₂₇N₅O₂
SMILES

C=CC(N1C[C@@H](N2N=C(C3=CC=CC(/C=C/C4=NC=C(C5CC5)O4)=C3)C(C6=CC=NC=C6)=C2)CC1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Clare Thomson, et al. Discovery and Optimization of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations. J Med Chem. 2024 Jun 13;67(11):8988-9027. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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AZ14133346

All EGFR Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

AZ14133346 Related Classifications

HY-163663 Related Classifications