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Cat. No.: HY-189413

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BChE-IN-55

BChE-IN-55 is a reversible competitive inhibitor of butyrylcholinesterase (BChE) and acetylcholinesterase (AChE), with IC₅₀ values of 2.91 μM (eqBChE) and 34.42 μM (eeAChE), respectively. BChE-IN-55 exhibits antioxidant activity. BChE-IN-55 can be used for research on Alzheimer's disease.

For research use only. We do not sell to patients.

Formula: C₁₁H₇Cl₃N₂O₂S₂
Molecular Weight:369.67

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

BChE-IN-55 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Protocols (2)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]

eqBCHE

2.91 μM (IC₅₀)

electric eel AChE

34.42 μM (IC₅₀)

All Cholinesterase (ChE) Isoforms :

AChE
BChE

In Vitro

BChE-IN-55 (Compound 1h) (2.9-29 µM; 10 min) exhibits antioxidant capacity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

Molecular Weight 369.67
Formula C₁₁H₇Cl₃N₂O₂S₂
SMILES

O=C(NC1=CC(Cl)=C(Cl)C(Cl)=C1)CN2C(SCC2=O)=S
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology Animals and Diseases

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Alzheimer’s Disease Modeling
Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by a progressive decline in cognitive functions and loss of specific types of neurons and synapses. Alzheimer's symptoms can be simulated in mice by injecting drugs (such as Aβ) or genetically modified.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Enikő Šikorová, et al. Rhodanine and 2,4-Dioxothiazolidine-based Amides: Synthesis and Evaluation as Dual-Action Cholinesterase Inhibitors and Antioxidants. RSC Med. Chem. 2026

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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