1. Protein Tyrosine Kinase/RTK
  2. Bcr-Abl
  3. BCR-ABL-IN-3

BCR-ABL-IN-3 

Cat. No.: HY-136526
Handling Instructions

BCR-ABL-IN-3 is a potent and irreversible Bcr-Abl inhibitor with an IC50 of ≤100 nM for Ba/F3Bcr-AblT3151. BCR-ABL-IN-3 has anti-cancer activity.

For research use only. We do not sell to patients.

BCR-ABL-IN-3 Chemical Structure

BCR-ABL-IN-3 Chemical Structure

CAS No. : 2240191-12-0

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Description

BCR-ABL-IN-3 is a potent and irreversible Bcr-Abl inhibitor with an IC50 of ≤100 nM for Ba/F3Bcr-AblT3151. BCR-ABL-IN-3 has anti-cancer activity[1].

IC50 & Target[1]

Ba/F3Bcr-AblT3151

≤100 nM (IC50)

In Vivo

BCR-ABL-IN-3 (compound 7; 15 mg/kg; twice a day; for 19 days) has good antitumor effect in female NOD/SCID mice of 7-8 weeks weighing 21.8 g with Ba/F3Bcr-AblT3151 cells[1].
BCR-ABL-IN-3 (2 mg/kg for IV or 20mg/kg for PO) has a Cmax of 5485 ng/mL and an AUC of 5450 h•ng/mL for IV in male Sprague Dawley rats of 7-8 weeks old weighing 210 g[1].

Molecular Weight

466.89

Formula

C₂₀H₁₇ClF₂N₄O₃S

CAS No.

2240191-12-0

SMILES

O=C(C1=CC(C2=CSN=C2)=C(N3C[[email protected]](O)CC3)N=C1)NC4=CC=C(OC(F)(Cl)F)C=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

BCR-ABL-IN-3Bcr-AblBa/F3Bcr-AblT3151anti-cancer,Inhibitorinhibitorinhibit

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