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  4. Brequinar sodium

Brequinar sodium  (Synonyms: DuP785 sodium; NSC 368390 sodium)

Cat. No.: HY-108325A
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Brequinar (sodium) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

For research use only. We do not sell to patients.

CAS No. : 96201-88-6

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Customer Review

Based on 28 publication(s) in Google Scholar

Other Forms of Brequinar sodium:

Brequinar sodium Related Antibodies

Top Publications Citing Use of Products

28 Publications Citing Use of MCE Brequinar sodium

Microbiological Assay
In Vivo Efficacy Study
Histological Imaging/Staining
Bio/Physico-chemical Assay

    Brequinar sodium purchased from MedChemExpress. Usage Cited in: Nature. 2024 Feb;626(7998):411-418.  [Abstract]

    Mitochondrial lipid peroxidation assessment of HT1080 treated with RSL3 (0.5 μM) and BQR (Brequinar 200 μM) for 2 h after pretreatment of 7-DHC (25 μM) and Fer-1 for 24 h.

    Brequinar sodium purchased from MedChemExpress. Usage Cited in: Nature. 2022 Apr;604(7904):134-140.  [Abstract]

    Anti-SARS2 activity of Brequinar (0-10 μM, 1 h pretreatment and infected for 40-48 h).

    Brequinar sodium purchased from MedChemExpress. Usage Cited in: Nature. 2022 Apr;604(7904):134-140.  [Abstract]

    Lungs analyzed for viral titer by plaque assay. Wild type Balb/C mice were treated with Brequinar (IP) and/or molnupiravir (EIDD-2801) (PO) daily at the indicated concentrations starting 24 h after infection. Mice (N = 5 mice per group) were intranasally inoculated with 1×10^5 PFU/mouse of SARS-CoV-2/B.1.351.

    Brequinar sodium purchased from MedChemExpress. Usage Cited in: Nature. 2022 Apr;604(7904):134-140.  [Abstract]

    Lungs quantified for interstitial inflammation. Wild type Balb/C mice were treated with Brequinar (IP) and/or molnupiravir (EIDD-2801) (PO) daily at the indicated concentrations starting 24 h after infection. Mice (N = 5 mice per group) were intranasally inoculated with 1×10^5 PFU/mouse of SARS-CoV-2/B.1.351.

    Brequinar sodium purchased from MedChemExpress. Usage Cited in: Nature. 2022 Apr;604(7904):134-140.  [Abstract]

    Lungs fixed in 4% PFA for H&E staining (Scale bar = 200 μm). Wild type Balb/C mice were treated with Brequinar (IP) and/or molnupiravir (EIDD-2801) (PO) daily at the indicated concentrations starting 24 h after infection. Mice (N = 5 mice per group) were intranasally inoculated with 1×10^5 PFU/mouse of SARS-CoV-2/B.1.351.

    • Biological Activity

    • Purity & Documentation

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    Description

    Brequinar (sodium) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

    Cellular Effect
    Cell Line Type Value Description References
    A-375 IC50
    8.1 μM
    Compound: Breq
    Antiproliferative activity against human A375 cells for 24 hrs by MTT assay
    Antiproliferative activity against human A375 cells for 24 hrs by MTT assay
    		[PMID: 24929289]
    BXPC-3 IC50
    0.94 μM
    Compound: Brequinar Sodium
    Cytotoxicity against human BxPC3 cells assessed as decrease in cell proliferation after 72 hrs by MTT reduction assay
    Cytotoxicity against human BxPC3 cells assessed as decrease in cell proliferation after 72 hrs by MTT reduction assay
    		10.1039/C6MD00179C
    HCT-116 IC50
    0.158 μM
    Compound: Brequinar Sodium
    Cytotoxicity against human HCT116 cells assessed as decrease in cell proliferation after 72 hrs by MTT reduction assay
    Cytotoxicity against human HCT116 cells assessed as decrease in cell proliferation after 72 hrs by MTT reduction assay
    		10.1039/C6MD00179C
    Hep 3B2 IC50
    10.22 μM
    Compound: Breq
    Antiproliferative activity against human Hep3B cells for 24 hrs by MTT assay
    Antiproliferative activity against human Hep3B cells for 24 hrs by MTT assay
    		[PMID: 24929289]
    HT-29 IC50
    13.98 μM
    Compound: Brequinar sodium
    Antiproliferative activity against human HT-29 cells after 48 hrs by MTT assay
    Antiproliferative activity against human HT-29 cells after 48 hrs by MTT assay
    		[PMID: 30738663]
    MDA-MB-231 IC50
    12.45 μM
    Compound: Brequinar sodium
    Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay
    Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay
    		[PMID: 30738663]
    WI-38 IC50
    33.954 μM
    Compound: Brequinar Sodium
    Cytotoxicity against human WI38 cells assessed as decrease in cell proliferation after 72 hrs by MTT reduction assay
    Cytotoxicity against human WI38 cells assessed as decrease in cell proliferation after 72 hrs by MTT reduction assay
    		10.1039/C6MD00179C
    In Vitro

    Potent and selective DHODH inhibitors

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Brequinar sodium Related Antibodies
    Molecular Weight

    397.35

    Formula

    C23H14F2NNaO2
    CAS No.
    SMILES

    O=C(C1=C(C)C(C2=CC=C(C3=CC=CC=C3F)C=C2)=NC4=CC=C(F)C=C14)O[Na]
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
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    • If you have published this work, please enter the PubMed ID.
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    Brequinar sodium Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Brequinar96201-88-6DuP785NSC 368390DuP 785DuP-785NSC368390NSC-368390Biochemical Assay Reagentsbiochemical reagentbiological materialorganic compoundlife scienceInhibitorinhibitorinhibit

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