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BSc3094 

Cat. No.: HY-141660
Handling Instructions

BSc3094 is a Tau aggregation inhibitor. BSc3094 can be used for the research of Alzheimer's disease (AD).

For research use only. We do not sell to patients.

BSc3094 Chemical Structure

BSc3094 Chemical Structure

CAS No. : 946857-84-7

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Description

BSc3094 is a Tau aggregation inhibitor. BSc3094 can be used for the research of Alzheimer's disease (AD)[1].

IC50 & Target

Tau aggregation[1]

In Vivo

BSc3094 (3 mg/kg; i.v.) direct intraventricular administration reduces sarkosyl-insoluble Tau[1].
BSc3094 (0.075~1.5 mM; intraventricular administration) reduces the levels of sarkosyl-insoluble Tau in cortical extracts by ≈70%[1].
BSc3094 reverses the pre-synaptic impairment in organotypic hippocampal slices from pro-aggregant mice, by reversing the pairedpulse depression observed in non-treated pro-aggregant Tau slices after applying a paired-pulse stimulus of the Schaffer collaterals. BSc3094 reverses the increase in Tau phosphorylation levels in rTg4510 mice down to control level. BSc3094 partially reversed the memory deficits in rTg4510 mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice[1]
Dosage: 3 mg/kg
Administration: I.v.
Result: Direct intraventricular administration reduced sarkosyl-insoluble Tau.
Animal Model: rTg4510 mice[1]
Dosage: 0.075~1.5 mM
Administration: Intraventricular administration
Result: Reduced the levels of sarkosyl-insoluble Tau in cortical extracts by ≈70%.
Molecular Weight

380.38

Formula

C₁₇H₁₂N₆O₃S

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

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BSc3094
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