AChE-IN-9
AChE-IN-9 is a Tacrine (HY-111338) glycoconjugate tethered with acetylated β-Glucose. AChE-IN-9 is also an AChE inhibitor with an IC50 value of 0.4 μM, with lower hepatotoxicity on healthy cells. Tacrine is used in Alzheimer's research.
For research use only. We do not sell to patients.
- Formula: C30H35N5O9
- Molecular Weight:609.63
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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AChE 0.4 μM (IC50) |
Tacrine (HY-111338) is mainly metabolized by CYP 1A2, but its glycoconjugates have shown more affinity towards CYP 3A4 rather than CYP 1A2[1].
AChE-IN-9 (compound A-1) (200 μM; 24 h) is non-toxic on HePG2 cell line with 100% cell viability, and shows lower hepatotoxicity than Tacrine (HY-111338) on healthy HepG2 cells[1].
AChE-IN-9 (10 μM; 24 h) inhibits AChE activity with inhibition rate of 96.6%[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 609.63
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Formula C30H35N5O9
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SMILES
CC(OC[C@H]1O[C@@H]([C@@H]([C@H]([C@@H]1OC(C)=O)OC(C)=O)OC(C)=O)N2C=C(N=N2)CNC3=C4CCCCC4=NC5=CC=CC=C53)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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