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Cat. No.: HY-121242

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Buthidazole

Name: Buthidazole
Brand: MedChemExpress
SKU: HY-121242
Availability: PreOrder

(Synonyms: VEL-5026)

Buthidazole (VEL-5026) is a Herbicide. Buthidazole targets photosynthesis as its most sensitive and first-inhibited process, and inhibits RNA synthesis, lipid synthesis, and anthocyanin biosynthesis, while transiently stimulating dark respiration. Buthidazole reduces or prevents starch accumulation in bundle sheath chloroplasts, causing swelling and ultrastructural damage of mesophyll chloroplasts. Buthidazole damages corn seedlings at high doses.

For research use only. We do not sell to patients.

CAS No.: 55511-98-3
Formula: C₁₀H₁₆N₄O₂S
Molecular Weight:256.32

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

Buthidazole Chemical Structure

CAS No.: 55511-98-3

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Biological Activity
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Biological Activity

Description

All DNA/RNA Synthesis Isoforms :

In Vitro

Lipid MetabolismNucleotide MetabolismProtein/Amino Acid MetabolismOthers

Lipid Metabolism

Buthidazole (0.1-100 µM; 30-120 min) inhibits lipid synthesis in isolated Phaseolus vulgaris cv. "Tuscola" leaf cells, reaching 84% inhibition at 100 µM after 120 min^[2].

Nucleotide Metabolism

Buthidazole (0.1-100 µM; 30-120 min) inhibits RNA synthesis in isolated Phaseolus vulgaris cv. "Tuscola" leaf cells, reaching 50% inhibition at 100 µM after 120 min^[2].

Protein/Amino Acid Metabolism

Buthidazole (0.1-100 µM; 30-120 min) does not significantly inhibit protein synthesis in isolated Phaseolus vulgaris cv. "Tuscola" leaf cells, with an inhibition rate of ≤14% at 100 µM^[2].

Others

Buthidazole (0.56-2.24 kg/ha; 12-24 days after pre-emergence application) inhibits total photosynthesis in Pioneer 3780 maize as early as 12 days after pre-emergence application at 2.24 kg/ha, whereas 0.56 and 1.12 kg/ha have no effect; dark respiration is essentially unaffected, with only a transient increase occurring at 0.56 kg/ha^[1].
Buthidazole (0.28-1.12 kg/ha; 14 days after pre-emergence application) inhibits anthocyanin formation in the first leaf sheath of Pioneer 3780 maize at 0.28-1.12 kg/ha by 14 days after pre-emergence application, with 0.56 kg/ha producing the lowest absorbance (0.082) at 525 nm^[1].
Buthidazole (0.1-100 µM; 30-120 min) inhibits photosynthesis in isolated Phaseolus vulgaris cv. "Tuscola" leaf cells, with 0.1 µM inhibiting 27-44% within 30-120 min and 100 µM inhibiting 86-88%^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 55511-98-3
Molecular Weight 256.32
Formula C₁₀H₁₆N₄O₂S
SMILES

O=C1N(C(CN1C)O)C2=NN=C(C(C)(C)C)S2
Synonyms

VEL-5026
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hatzios KK, et al. Some effects of buthidazole on corn (Zea mays) photosynthesis, respiration, anthocyanin formation, and leaf ultrastructure. Weed Science. 1980 Jan;28(1):97-100.

[2]. Hatzios KK, et al. Localizing the action of two thiadiazolyl herbicidal derivatives. Pesticide Biochemistry and Physiology. 1980 Jun 1;13(3):237-43.

[3]. Hatzios KK, et al. Potential antidotes against buthidazole injury to corn (Zea mays). Weed Science. 1980 May;28(3):273-6.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Buthidazole

All DNA/RNA Synthesis Isoforms

Biological Activity

Description

In Vitro

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Bioz

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Buthidazole

All DNA/RNA Synthesis Isoforms

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