Davutamig
Based on 1 Customer Validation
Davutamig (REGN-5093) is a human IgG4-kappa, anti-MET bispecific antibody. Davutamig binds 2 distinct epitopes of MET, blocking ligand binding and inducing MET internalization and degradation. Davutamig is applicable to the research of advanced non-small cell lung cancer with MET gene abnormalities.
For research use only. We do not sell to patients.
- Purity: ≥99.0%
- CAS No.: 2648058-48-2
- Molecular Weight:144.62 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Human IgG4 kappa
Human
c-MET
Davutamig blocks the binding of hepatocyte growth factor (HGF) to MET, thereby inhibiting the activation of the MET signaling pathway. Meanwhile, this unique binding pattern also induces internalization and degradation of the MET receptor, completely eliminating MET protein on the surface of tumor cells to achieve a stronger anti-tumor effect[1][2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Human IgG4 kappa (H435R and Y436F)
ELISA, FACS, Functional assay
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Flow Cytometry analysis of A549 cells labelling c-MET (red) with Davutamig (anti-c-MET) (HY-P990073). Cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa (HY-P99003, blue) was used as the isotype control.
Chemical Information
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CAS No. 2648058-48-2
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Appearance Liquid
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Molecular Weight 144.62 kDa
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Color Colorless to light yellow
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SMILES
[Davutamig]
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Synonyms
REGN-5093
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (256 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)