Dazostinag
Based on 1 publication(s) in Google Scholar
Dazostinag (TAK-676 free base) is an agonist of stimulator of interferon genes (STING) protein with antineoplastic activity. Dazostinag can serve as a playload to synthesis antibody-drug conjugates (ADCs).
For research use only. We do not sell to patients.
- CAS No.: 2553413-86-6
- Formula: C21H22F2N8O10P2S2
- Molecular Weight:710.52
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Dazostinag
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Biological Activity
Dazostinag (ADC-1, linker-payload) (121 μM; 10 min-24 hr) exhibits an half-life (t1/2) of 2.4 hr in rat liver tritosomes[1].
Dazostinag (ADC-1, linker-payload) activates human Guanylyl cyclase C (GCC) with an EC50 value of 0.068 nM in THPl cells with R232 variant of human STING[1].
Dazostinag (ADC-1) (10 μg/mL; 0-96 hr) shows plasma stability in human, primate and mouse plasma[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Dazostinag (ADC-1) (50 μg/kg, 100 μg/kg; i.v.; single dose, monitored for 2 weeks) significantly inhibits the growth of tumor in Balb/C mouse bearing GCC-expressing CT26 colon carcinoma mouse tumors[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:CT26 colon carcinoma model in female Balb/C mice (6-8 weeks old)[1]
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Dosage:50 μg/kg, 100 μg/kg
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Administration:IP; single dose, monitored for 15 days, measured two times per week
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Result:Significantly suppressed the volume of tumor in mice.
Chemical Information
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CAS No. 2553413-86-6
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Molecular Weight 710.52
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Formula C21H22F2N8O10P2S2
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SMILES
FC1=CN([C@H]2[C@H](O[P@@](OC[C@@H]3[C@@H](O4)[C@@H](F)[C@H](N5C6=NC=NC(N)=C6N=C5)O3)(S)=O)[C@H](O)[C@@H](COP4(S)=O)O2)C7=C1C(N=CN7)=O
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Synonyms
TAK-676 free base
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Science
2026 May 7;392(6798):eadx1893. PMID: 42096576
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Dazostinag Related Classifications
HY-152861 Related Classifications
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