Desacetylbufotalin
Desacetylbufotalin (Bufogenin B; Deacetylbufotalin) is a bufadienolide found in Chinese drug "Chan'Su". Desacetylbufotalin shows strong anti-proliferative activity on the of Hela cells (IC50 = 0.01 μM). Desacetylbufotalin can be used for the research of cancer, such as cervical cancer.
For research use only. We do not sell to patients.
- CAS No.: 465-19-0
- Formula: C24H34O5
- Molecular Weight:402.52
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| CCRF S-180 | IC50 |
>50 μM
Compound: 3
|
Cytotoxicity against mouse S180 cells expressing mutated alpha-1 Na+/K+-ATPase assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against mouse S180 cells expressing mutated alpha-1 Na+/K+-ATPase assessed as growth inhibition after 48 hrs by MTT assay
|
[PMID: 23799775] |
| CNE | IC50 |
4.893 μM
Compound: 3
|
Cytotoxicity against human CNE1 cells assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human CNE1 cells assessed as growth inhibition after 48 hrs by MTT assay
|
[PMID: 23799775] |
| CNE2Z | IC50 |
1.765 μM
Compound: 3
|
Cytotoxicity against human CNE2Z cells assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human CNE2Z cells assessed as growth inhibition after 48 hrs by MTT assay
|
[PMID: 23799775] |
| H22 | IC50 |
>50 μM
Compound: 3
|
Cytotoxicity against mouse H22 cells expressing mutated alpha-1 Na+/K+-ATPase assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against mouse H22 cells expressing mutated alpha-1 Na+/K+-ATPase assessed as growth inhibition after 48 hrs by MTT assay
|
[PMID: 23799775] |
| HepG2 | IC50 |
2.595 μM
Compound: 3
|
Cytotoxicity against adriamycin-resistant human HepG2 cells assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against adriamycin-resistant human HepG2 cells assessed as growth inhibition after 48 hrs by MTT assay
|
[PMID: 23799775] |
| HepG2 | IC50 |
3.584 μM
Compound: 3
|
Cytotoxicity against human HepG2 cells assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as growth inhibition after 48 hrs by MTT assay
|
[PMID: 23799775] |
| HL-60 | IC50 |
0.025 μg/mL
Compound: 18
|
Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
|
[PMID: 11575946] |
| KB | IC50 |
0.79 μg/mL
Compound: 18
|
Cytotoxicity against human KB cells after 72 hrs by MTT assay
Cytotoxicity against human KB cells after 72 hrs by MTT assay
|
[PMID: 11575946] |
| MH60 | IC50 |
>25 μg/mL
Compound: 18
|
Cytotoxicity against mouse MH60 cells after 72 hrs by MTT assay
Cytotoxicity against mouse MH60 cells after 72 hrs by MTT assay
|
[PMID: 11575946] |
Chemical Information
-
CAS No. 465-19-0
-
Molecular Weight 402.52
-
Formula C24H34O5
-
SMILES
O[C@@]12[C@@]([C@@H](C(C=C3)=COC3=O)[C@H](C1)O)(CC[C@@]4([H])[C@@]2([H])CC[C@@]5([H])[C@@]4(CC[C@@H](C5)O)C)C
-
Synonyms
Bufogenin B; Deacetylbufotalin
-
Structure Classification
-
Initial Source
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Desacetylbufotalin Related Classifications
HY-N16671 Related Classifications
Powered by Bioz