Dimethyl succinate
Based on 2 publication(s) in Google Scholar
Dimethyl succinate is an orally active cell permeable succinate analogue. Dimethyl succinate can disrupt the TCA cycle by elevating intracellular succinate levels, leading to reduced protein synthesis and impairs myogenic differentiation. Dimethyl succinate can induce apoptosis. Dimethyl succinate can decrease maximal cellular respiration and reserve capacity. Dimethyl succinate can rescue synapse loss in AD. Dimethyl succinate can be used for the researches of metabolic and neurological disease[1][2].
For research use only. We do not sell to patients.
- Purity: 99.95%
- CAS No.: 106-65-0
- Formula: C6H10O4
- Molecular Weight:146.14
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Dimethyl succinate
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Customer Validation & Images
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Flow Cytometry
Biological Activity
Dimethyl succinate (16 mM) increases apoptotic cells in C2C12 myoblasts[1].
Dimethyl succinate (4-8 mM, 48 h) increases intracellular succinate, malate and glutamate in C2C12 myoblasts[1].
Dimethyl succinate (8 mM, 48 h) reduces protein anabolism as determined by an O-propargyl-puromycin (OPP) incorporation assay in C2C12 myoblasts[1].
Dimethyl succinate (8 mM) reduces maximal respiration and mitochondria reserve capacity in C2C12 myoblasts[1].
Dimethyl succinate (8 mM) results in an impaired ability to form mature, multinucleated Myosin Heavy Chain-positive structures in C2C12 myoblasts[1].
Dimethyl succinate (5 mM, 48 h) partially rescues synapse loss in AD hiPSC-derived cerebrocortical neurons[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:C2C12 myoblasts
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Concentration:4 mM, 8 mM, 16 mM
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Incubation Time:48 hours
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Result:Showed no significant differences in proliferation over this time period.
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Cell Line:C2C12 myoblasts
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Concentration:4 mM, 8 mM, 16 mM
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Incubation Time:48 hours
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Result:Only increased apoptosis rates at 16 mM.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:FVB mice; wild type model[1]
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Dosage:2% in water
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Administration:Oral; 6 weeks
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Result:Had no significant difference in total body weight and total lean mass.
Impaired skeletal muscle homeostasis and regeneration.
Exhibited smaller muscle myofiber diameters.
Chemical Information
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CAS No. 106-65-0
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Appearance <16°C Solid,>19°C Liquid
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Molecular Weight 146.14
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Formula C6H10O4
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Color Colorless to off-white
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SMILES
O=C(OC)CCC(OC)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (2)
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Journal Impact Factor
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Most Recent
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Cell Rep
4-octyl itaconate inhibits cytokine-mediated inflammation via alkylation of TYK2 and JAK1. [Abstract]2026 Mar 30;45(4):117179. PMID: 41915469 -
Chin Med
Acacetin alleviates autoimmune myocarditis by regulating CD4+ T cell mitochondrial respiration. [Abstract]2024 May 13;19(1):68. PMID: 38741130
Dimethyl succinate purchased from MedChemExpress. Usage Cited in: Chin Med. 2024 May 13;19(1):68. [Abstract]
Dimethyl succinate (DES) (5 mM; 72 h) reversed the decrease of CD44 expression and proliferation of CD4+ T cells by acacetin.
Solvent & Solubility
DMSO : 200 mg/mL (1368.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : ≥ 100 mg/mL (684.28 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: Saline
Solubility: ≥ 100 mg/mL (684.28 mM); Clear solution
Purity & Documentation
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Data Sheet (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Arneson-Wissink PC, et al. The wasting-associated metabolite succinate disrupts myogenesis and impairs skeletal muscle regeneration. JCSM Rapid Commun. 2020;3(2):56-69. [Content Brief]
[2]. Andreyev AY, et al. Metabolic Bypass Rescues Aberrant S-nitrosylation-Induced TCA Cycle Inhibition and Synapse Loss in Alzheimer's Disease Human Neurons. Adv Sci (Weinh). 2024;11(12):e2306469. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 6.8428 mL | 34.2138 mL | 68.4275 mL | 171.0688 mL |
| 5 mM | 1.3686 mL | 6.8428 mL | 13.6855 mL | 34.2138 mL | |
| 10 mM | 0.6843 mL | 3.4214 mL | 6.8428 mL | 17.1069 mL | |
| 15 mM | 0.4562 mL | 2.2809 mL | 4.5618 mL | 11.4046 mL | |
| 20 mM | 0.3421 mL | 1.7107 mL | 3.4214 mL | 8.5534 mL | |
| 25 mM | 0.2737 mL | 1.3686 mL | 2.7371 mL | 6.8428 mL | |
| 30 mM | 0.2281 mL | 1.1405 mL | 2.2809 mL | 5.7023 mL | |
| 40 mM | 0.1711 mL | 0.8553 mL | 1.7107 mL | 4.2767 mL | |
| 50 mM | 0.1369 mL | 0.6843 mL | 1.3686 mL | 3.4214 mL | |
| 60 mM | 0.1140 mL | 0.5702 mL | 1.1405 mL | 2.8511 mL | |
| 80 mM | 0.0855 mL | 0.4277 mL | 0.8553 mL | 2.1384 mL | |
| 100 mM | 0.0684 mL | 0.3421 mL | 0.6843 mL | 1.7107 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Dimethyl succinate Related Classifications
HY-Y0808 Related Classifications
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