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Cat. No.: HY-179334

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DMA-155

DMA-155 is an antiviral agent with binding activity against SARS-CoV-2 5'-terminal stem-loop RNAs, with affinities of 51.1 μM (SL1), 61.1 μM (SL4), 54.5 μM (SL5a), 66.9 μM (SL5b) and 48.6 μM (SL6), respectively. DMA-155 inhibits SARS-CoV-2 viral replication and reduces SARS-CoV-2 viral RNA levels. DMA-155 is applicable to the research of COVID-19.

For research use only. We do not sell to patients.

CAS No.: 2237925-69-6
Formula: C₂₀H₂₁N₇O
Molecular Weight:375.43

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Please store the product under the recommended conditions in the Certificate of Analysis.

DMA-155 Chemical Structure

CAS No.: 2237925-69-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
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Chemical Information
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Biological Activity

Description

All DNA/RNA Synthesis Isoforms :

In Vitro

DMA-155 (50-100 μM; 24 h) significantly inhibits human coronavirus OC43 replication in Vero E6 cells when administered at 50 μM or 100 μM for 24 hours^[1].
DMA-155 (24-72 h) potently inhibits SARS-CoV-2 replication in Vero E6 cells with an IC₅₀ of 16 μM at 24 hours post-infection, with sustained dose-dependent activity through 72 hours^[1].
DMA-155 (10 μM; 72 h) inhibits SARS-CoV-2 replication in Vero E6 cells at 10 μM for 72 hours without significant cellular toxicity^[1].
DMA-155 (0.1-100 μM; 2 days) specifically inhibits SARS-CoV-2 5'-UTR-dependent translation in Vero E6 cells, with a ~90% reduction in FLuc activity at 10 μM after 2 days of incubation, without non-specific effects on translation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2237925-69-6
Molecular Weight 375.43
Formula C₂₀H₂₁N₇O
SMILES

O=C(C1=C(N)N=C(N(C)C)C(C2=CC=C(C3=CC=CC=C3)C=C2)=N1)NC(N)=N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Amanda HARGROVE, et al. Amiloride derivatives and methods of using same for the treatment of viral infections. WO2022120150A1.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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- In Vitro
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Purity & Documentation
References

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DMA-155

All DNA/RNA Synthesis Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

DMA-155 Related Classifications

HY-179334 Related Classifications