G3-YSD
Based on 1 Customer Validation
G3-YSD is a cGAS agonist. G3-YSD directly interacts with cGAS to enhance its enzymatic activity, promote the conversion of ATP and GTP into cGAMP, and trigger STING-dependent IFN-α/β secretion. G3-YSD acts as a viral mimic to replace actual viral DNA. G3-YSD is applicable to research related to long COVID and type 1 human immunodeficiency virus infection.
For research use only. We do not sell to patients.
- Purity: 98.37%
- CAS No.: 2780391-08-2
- Molecular Weight:8088.29
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Stimulation with G3-YSD (1 mg/mL; 24 h) induces significant type I interferon (IFN-I) biological activity in peripheral blood mononuclear cells (PBMCs) from Microx long COVID patients[1].
G3-YSD (0.8 µg/mL; 20 h) potently induces IFN-α secretion from Chloroquine (HY-17589A)-treated human peripheral blood mononuclear cells in a guanosine-dependent manner. It maintains stable activity across a core double-strand length range of 12-28 bp and tolerates small mismatches/bulges in the core double strand[2].
G3-YSD (0.8 µg/mL; 20-36 h) potently induces IFN-α secretion in primary human monocytes and monocyte-derived macrophages, and its activity in macrophages is comparable to that of long-chain HIV-1 ssDNA[2].
G3-YSD (1.3 µg/mL; 20 h) induces IFN-α/β secretion in the human monocyte cell line THP-1 solely via the cGAS-STING signaling axis[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2780391-08-2
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Appearance Solid
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Molecular Weight 8088.29
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Color White to off-white
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SMILES
[DNA, d(G-G-G-T-A-T-A-T-A-T-A-T-G-C-A-T-A-T-A-T-A-T-A-G-G-G)]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Purity & Documentation
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Data Sheet (263 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2242 KB)
References
[1]. Humer B, et al. Exaggerated IFN-I Response in Long COVID PBMCs Following Exposure to Viral Mimics. J Clin Immunol. 2025;46(1):5. Published 2025 Dec 10. [Content Brief]
[2]. Herzner AM, et al. Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA. Nat Immunol. 2015;16(10):1025-1033. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
G3-YSD Related Classifications
HY-171692 Related Classifications
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