Rorc - RAR-related orphan receptor C Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 368158

About Rorc

Primary_assembly 2: 182,009,286-182,034,907 forward strand.mRatBN7.2:CM026975.1

This gene has 4 transcripts (splice variants), 383 orthologues, 19 paralogues and is associated with 13 phenotypes. Biased expression in Thymus (RPKM 399.9), Liver (RPKM 124.) and 5 other tissues.

Summary

Predicted to enable several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; oxysterol binding activity; and transcription coactivator binding activity. Involved in circadian rhythm. Predicted to be located in external side of plasma membrane and nuclear body. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in immunodeficiency 42. Orthologous to human RORC (RAR related Orphan Receptor C). [provided by Alliance of Genome Resources, Apr 2022]

Rorc Products (4)

mRNA Protein Name
XM_017591313.2 XP_017446802.1 nuclear receptor ROR-gamma isoform X2
XM_039103783.1 XP_038959711.1 nuclear receptor ROR-gamma isoform X3
XM_006232926.4 XP_006232988.2 nuclear receptor ROR-gamma isoform X1
XM_039103784.1 XP_038959712.1 nuclear receptor ROR-gamma isoform X4

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in circadian rhythm IEP
IEP: Inferred from expression pattern
15781226 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Rorc Protein Structure

NR_DBD_ROR

NR_DBD_ROR: cd06968 (23 - 117)

NR_LBD_ROR_like

NR_LBD_ROR_like: cd06939 (257 - 495)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 508 a.a.
Protein Preferred Names Protein Names

nuclear receptor ROR-gamma

  • RAR-related orphan receptor gamma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-19775 GNE-6468 Antagonist 98.02% Unkown
HY-112706 PF-06747711 Antagonist 99.83% Unkown
HY-19774 GNE-0946 Inhibitor 98.11% Unkown
HY-16983 GNE-3500 Antagonist 98.90% Unkown
HY-RS12132 RORC Human Pre-designed siRNA Set A / Unkown
HY-128353 ROR agonist-1 Antagonist / Unkown
HY-148237 JNJ-54119936 Antagonist / Unkown
HY-RS12133 Rorc Mouse Pre-designed siRNA Set A / Unkown
HY-RS12134 Rorc Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-180865 RORC modulator-1 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rorc NCBI NCBI:6097