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Cat. No.: HY-141426

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MDL-860

MDL-860 is a broad-spectrum antipicornavirus compound that has low cytotoxicity toward human cells. MDL-860 can be used for the research of virus infection.

For research use only. We do not sell to patients.

CAS No.: 78940-62-2
Formula: C₁₃H₆Cl₂N₂O₃
Molecular Weight:309.10

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

MDL-860 Chemical Structure

CAS No.: 78940-62-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

MDL-860 is a broad-spectrum antipicornavirus compound that has low cytotoxicity toward human cells. MDL-860 can be used for the research of virus infection^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HEp-2	CC₅₀	493 μM Compound: MDL-860; DNB	Cytotoxicity against human Hep2 cells assessed as decrease in cell viability after 48 hrs by neutral red uptake assay Cytotoxicity against human Hep2 cells assessed as decrease in cell viability after 48 hrs by neutral red uptake assay	[PMID: 28870395]
Vero	EC₅₀	5.84 μM Compound: DPN	Effective concentration required to inhibit Coxsackie B3 virus induced cytopathicity in vero cells Effective concentration required to inhibit Coxsackie B3 virus induced cytopathicity in vero cells	[PMID: 15658858]
Vero	IC₅₀	>50 μM Compound: 13; MDL860	Cytotoxicity against African green monkey Vero cells assessed by reduction in cell viability incubated for 72 hrs by resazurin dye fluorescence based assay Cytotoxicity against African green monkey Vero cells assessed by reduction in cell viability incubated for 72 hrs by resazurin dye fluorescence based assay	[PMID: 34046598]

Chemical Information

CAS No. 78940-62-2
Molecular Weight 309.10
Formula C₁₃H₆Cl₂N₂O₃
SMILES

N#CC1=CC([N+]([O-])=O)=CC=C1OC2=CC=C(Cl)C(Cl)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Nikolova I, et al. Anti-enteroviral activity of new MDL-860 analogues: Synthesis, in vitro/in vivo studies and QSAR analysis. Bioorg Chem. 2019 Apr;85:487-497. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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