NP7r
NP7r is an antioxidant and neuroprotective agent. NP7r regulates oxidative stress, upregulates downstream antioxidant genes, reduces mitochondrial ROS, initiates Autophagy and clears α-synuclein aggregates. NP7r alleviates dopaminergic neuron degeneration, restores fat content, reduces lipid peroxidation, and improves motor impairment and abnormal food perception. NP7r is applicable to the research of Parkinson's disease.
For research use only. We do not sell to patients.
- CAS No.: 2641092-28-4
- Formula: C26H20O3
- Molecular Weight:380.44
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
All α-synuclein Isoforms
More
Biological Activity
NP7r (10 μM) protects *Caenorhabditis elegans* against 6-OHDA (HY-B1081)-induced dopaminergic neuron degeneration, restoring the total fluorescence intensity of dopaminergic neurons to 96.28% of that in the control group[1].
NP7r (10 μM) alleviates 6-OHDA-induced growth and behavioral defects in wild-type *Caenorhabditis elegans*, restoring its movement and feeding-related behaviors to levels close to those of the control group[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:NL5901 pkIs2386 [unc-54p::alpha-synuclein:YFP + unc-119(+)][1]
-
Dosage:10 μM; 20 μM; 40 μM; 80 μM
-
Administration:nematode growth medium; 48 hours
-
Result:Significantly reduced mitochondrial ROS levels in NL5901 worms (effect dependent on skn-1 gene).
Decreased α-synuclein-YFP fluorescence intensity by ~30% relative to untreated controls.
Reduced MDA levels and partially restored lipid droplet area in NL5901 worms.
Upregulated mRNA levels of skn-1, gst-4, gcs-1, cct-2, cct-3, cct-4, cct-6, cct-7, cct-8, lgg-1, unc-51, epg-5, epg-8, vps-35, and atg-7.
Downregulated daf-16 and sod-3 mRNA levels.
Increased GSH levels and restored GST-4::GFP fluorescence intensity in 6-OHDA-treated CL2166 worms.
Confirmed α-synuclein clearance effect dependent on cct-6, lgg-1, and unc-51 genes.
-
Animal Model:BZ555 egls1[Pdat-1::gfp][1]
-
Dosage:10 μM
-
Administration:nematode growth medium; post-6-OHDA exposure
-
Result:Restored total dopaminergic neuron fluorescence intensity to 96.28% of untreated BZ555 levels, representing a 36.23% increase relative to 6-OHDA-only treated worms.
Restored fluorescence intensity of cephalic (CEP), anterior deirid (ADE), and posterior deirid (PDE) dopaminergic neurons.
-
Animal Model:N2[1]
-
Dosage:10 μM
-
Administration:nematode growth medium; post-6-OHDA exposure
-
Result:Restored 6-OHDA-reduced body length, tail thrashing frequency, slowing rate, travel distance, velocity, and body bend frequency in N2 worms to levels statistically comparable to untreated controls.
Chemical Information
-
CAS No. 2641092-28-4
-
Molecular Weight 380.44
-
Formula C26H20O3
-
SMILES
O=C1CCC2=C1C(C3=CC=CC=C3)=CC(C4=CC=C(C=C4)O)(O2)C5=CC=CC=C5
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NP7r Related Classifications
HY-184558 Related Classifications
Powered by Bioz