Penitrem B
Penitrem B (Tremortin B) is a dechlorinated indole diterpene tremorgen found in fungi such as Penicillium palitans and Aspergillus sulphureus. Penitrem B induces tremors, ataxia, and convulsions in mice. Penitrem B is used in research related to tremogenic mycotoxicosis and fungal infections.
For research use only. We do not sell to patients.
- CAS No.: 11076-67-8
- Formula: C37H45NO5
- Molecular Weight:583.76
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Description
In Vitro
Penitrem B exhibits weak or no cytotoxic activity against A549 and HL-60 cell lines[1].
Penitrem B is obtained by extraction and purification from Fernbach cultures of Penicillium palitans NRRL 3468, with a yield of approximately 25 mg[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Male mice (18-24 g)[2]
-
Dosage:1.38, 2.76, 5.52 and 11.04 mg/kg
-
Administration:i.p.; single dose
-
Result:Caused perceptible tremors at doses as low as 1.3 mg/kg which persisted for several hours.
Caused 3 deaths out of 4 animals at 5.52 mg/kg.
Caused 4 deaths out of 4 animals at 11.04 mg/kg.
Calculated an LD50 of 5.84 mg/kg with a 95% confidence interval of 4.13 to 8.26 mg/kg.
Chemical Information
-
CAS No. 11076-67-8
-
Molecular Weight 583.76
-
Formula C37H45NO5
-
SMILES
O[C@]12[C@]34[C@]([C@H]([C@H](O[C@]4([H])CC[C@@]1([C@]5(C6=C7[C@](OC(C)([C@]8([H])[C@@]9([H])C%10=C7C(N6)=CC=C%10CC([C@@]9([H])C8)=C)C)([H])[C@]5([H])CC2)C)C)C(C)=C)O)([H])O3
-
Synonyms
Tremortin B
-
Structure Classification
-
Initial Source
Penicillium crustosum
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Gao SS, et al. Rhizovarins A-F, Indole-Diterpenes from the Mangrove-Derived Endophytic Fungus Mucor irregularis QEN-189. J Nat Prod. 2016 Aug 26;79(8):2066-74. [Content Brief]
[4]. Moldes-Anaya A, et al. Neurotoxicity of Penicillium crustosum secondary metabolites: tremorgenic activity of orally administered penitrem A and thomitrem A and E in mice. Toxicon : official journal of the International Society on Toxinology. 2012 Dec 15;60(8):1428-35. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Penitrem B Related Classifications
HY-N22059 Related Classifications
Powered by Bioz